Academic Journal
Cyanoacrylate Adhesives for Cutaneous Wound Closure
| العنوان: | Cyanoacrylate Adhesives for Cutaneous Wound Closure |
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| المؤلفون: | Inácio Silva Viana, Paula Alessandra Di Filippo, Francielli Pereira Gobbi, Rachel Bittencourt Ribeiro, Gabriel João Unger Carra, Luiza Maria Feitosa Ribeiro, Lara de Souza Ribeiro, Michelle do Carmo Pereira Rocha, Paulo Aléscio Canola |
| المصدر: | Animals, Vol 14, Iss 18, p 2678 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Veterinary medicine LCC:Zoology |
| مصطلحات موضوعية: | inflammation, collagen, surgery, healing, resistance, Veterinary medicine, SF600-1100, Zoology, QL1-991 |
| الوصف: | Cyanoacrylate-based adhesives are widely used in wound closure, providing good cosmetic results and little discomfort. However, reports in the literature are found about negative effects that include the release of cytotoxic chemicals during biodegradation. In this study, we sought to evaluate and compare the effectiveness of four cyanoacrylate-based adhesives on the closure of skin incisions in Rattus norvegicus. The animals (n = 140) were divided into five groups of 28 animals each according to the wound closure technique: G1 and G2 (n-2-ethyl-cyanoacrylate); G3 (n-2-butyl-cyanoacrylate); G4 (n-2-octyl-cyanoacrylate); and G5 (5 nylon stitches). Midline incisions measuring 5.0 cm in length were created and closed using the different materials evaluated, and on D3, D7, D14, and D21, tensiometric and histopathological analyses were performed. Shorter wound closure and adhesion times were observed in G4 animals. At D3 and D7, G5 presented greater tensiometric resistance in the animals of G5, with a decrease in D14 and D21 compared to the other groups. On the other hand, the wounds of G3 and G4 were more resistant in D14 and D21, reaching maximum resistance values. Polymorphonuclear and mononuclear cells are more prevalent and more granulation tissue was observed in G5. The deposition of type III collagen was more evident in G5, whilst there was no difference in the amount of type I collagen in any of the groups treated with cyanoacrylate adhesives. Larger areas stained positive for VEGF-α in G2 and smaller areas in G4, with peaks at D7 and D14. In general, cyanoacrylate adhesives cause less intense inflammatory reactions, resulting in shorter healing times when compared to nylon sutures. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-2615 |
| Relation: | https://www.mdpi.com/2076-2615/14/18/2678; https://doaj.org/toc/2076-2615 |
| DOI: | 10.3390/ani14182678 |
| URL الوصول: | https://doaj.org/article/1e2a3ac62e9b4f35b8ed105f865c1ba9 |
| رقم الانضمام: | edsdoj.1e2a3ac62e9b4f35b8ed105f865c1ba9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20762615 |
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| DOI: | 10.3390/ani14182678 |