التفاصيل البيبلوغرافية
| العنوان: |
Myocardial infarction model induced by isoproterenol in rats and potential cardiovascular protective effect of a nattokinase-containing hard capsule |
| المؤلفون: |
Van Anh Pham, Ha Thai Tran, Thanh Phuong Mai, Lien Huong Nguyen, Van Hong Nguyen, Thang Huu Nguyen, Son Song Bui, An Van Vu, Ha Thanh Do, Quang Vinh Trinh |
| المصدر: |
Phytomedicine Plus, Vol 3, Iss 3, Pp 100472- (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Other systems of medicine |
| مصطلحات موضوعية: |
Isoproterenol-induced myocardial infarction, Nattokinase, Rat ECG, eNOS, Anti-oxidant activity, Other systems of medicine, RZ201-999 |
| الوصف: |
Background: TD.HK01® consists of a Japanese traditional medicine: Nattokinase (derived from soybean) and three other natural components, namely dried Hirudo medicinalis, Semen Mucuna interrupta and Huperzia carinata. Objectives: TD.HK01® is potentially aimed to the preventive treatment of cardiovascular disease (CVD) in general, and myocardial infarction (MI) in particular. Methods: In this study, a non-invasive method has been used to induce MI in rats, preceded by oral administration of TD.HK01® for 30 consecutive days to determine the potential cardiovascular effect of this pretreatment. Rats were divided into four groups: normal control group, ISO-induced group (isoproterenol (ISO), 150 mg/kg, s.c.) and two groups treated by TD.HK01® in different doses (0.31 and 0.92 g/kg, orally + ISO 150 mg/kg, s.c.). Results: TD.HK01® treated groups showed significant improvement as in abnormal electrocardiography (ECG) alteration ratio, in decreased biochemical specific markers troponin T and in decreased non-specific biochemical markers (LDH and AST) between each of TD.HK01® treated groups and ISO-induced group. The effect on vascular system was also evaluated through serum eNOS quantification and a notable increase in an anti-oxidative enzyme catalase. All three groups, except the normal control one, had pathological lesions in histopathology in different levels - modest injuries in treated groups and more severe in ISO-induced group. Conclusions: It is concluded on the basis of the findings that isoproterenol induced MI in all three groups and TD.HK01® did have its potential protective effect in vivo on cardiovascular system. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2667-0313 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2667031323000684; https://doaj.org/toc/2667-0313 |
| DOI: |
10.1016/j.phyplu.2023.100472 |
| URL الوصول: |
https://doaj.org/article/1dfcc46dc74f43a5a8f0bb0aef671fe4 |
| رقم الانضمام: |
edsdoj.1dfcc46dc74f43a5a8f0bb0aef671fe4 |
| قاعدة البيانات: |
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