Academic Journal
Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair
| العنوان: | Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair |
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| المؤلفون: | Yacine Kharraz, Joana Guerra, Christopher J. Mann, Antonio L. Serrano, Pura Muñoz-Cánoves |
| المصدر: | Mediators of Inflammation, Vol 2013 (2013) |
| بيانات النشر: | Wiley, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | Pathology, RB1-214 |
| الوصف: | Effective repair of damaged tissues and organs requires the coordinated action of several cell types, including infiltrating inflammatory cells and resident cells. Recent findings have uncovered a central role for macrophages in the repair of skeletal muscle after acute damage. If damage persists, as in skeletal muscle pathologies such as Duchenne muscular dystrophy (DMD), macrophage infiltration perpetuates and leads to progressive fibrosis, thus exacerbating disease severity. Here we discuss how dynamic changes in macrophage populations and activation states in the damaged muscle tissue contribute to its efficient regeneration. We describe how ordered changes in macrophage polarization, from M1 to M2 subtypes, can differently affect muscle stem cell (satellite cell) functions. Finally, we also highlight some of the new mechanisms underlying macrophage plasticity and briefly discuss the emerging implications of lymphocytes and other inflammatory cell types in normal versus pathological muscle repair. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0962-9351 1466-1861 |
| Relation: | https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861 |
| DOI: | 10.1155/2013/491497 |
| URL الوصول: | https://doaj.org/article/1df5bd2679c94fa7b9a2a50a6a63b3dc |
| رقم الانضمام: | edsdoj.1df5bd2679c94fa7b9a2a50a6a63b3dc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09629351 14661861 |
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| DOI: | 10.1155/2013/491497 |