التفاصيل البيبلوغرافية
| العنوان: |
Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells |
| المؤلفون: |
Myoung-Sik Han, Im-Ho Han, Dahae Lee, Jun Min An, Su-Nam Kim, Myoung-Sook Shin, Noriko Yamabe, Gwi Seo Hwang, Hye Hyun Yoo, Suk-Jung Choi, Ki Sung Kang, Hyuk-Jai Jang |
| المصدر: |
Journal of Ginseng Research, Vol 40, Iss 2, Pp 135-140 (2016) |
| بيانات النشر: |
Elsevier, 2016. |
| سنة النشر: |
2016 |
| المجموعة: |
LCC:Botany |
| مصطلحات موضوعية: |
cisplatin, ginsenoside 20(S)-Rg3, mitogen-activated protein kinases, nephrotoxicity, Panax ginseng, Botany, QK1-989 |
| الوصف: |
Background: Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines, and its individual constituents enhance renal function. Identification of its efficacy and mechanisms of action against drug-induced nephrotoxicity, as well as the specific constituents mediating this effect, have recently emerged as an interesting research area focusing on the kidney protective efficacy of P. ginseng. Methods: The present study investigated the kidney protective effect of fermented black ginseng (FBG) and its active component ginsenoside 20(S)-Rg3 against cisplatin (chemotherapy drug)-induced damage in pig kidney (LLC-PK1) cells. It focused on assessing the role of mitogen-activated protein kinases as important mechanistic elements in kidney protection. Results: The reduced cell viability induced by cisplatin was significantly recovered with FBG extract and ginsenoside 20(S)-Rg3 dose-dependently. The cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), p53, and cleaved caspase-3 were decreased after cotreatment with FBG extract or ginsenoside 20(S)-Rg3. The elevated percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment was significantly abrogated by cotreatment with FBG and the ginsenoside 20(S)-Rg3. Conclusion: FBG and its major ginsenoside 20(S)-Rg3, ameliorated cisplatin-induced nephrotoxicity in LLC-PK1 cells by blocking the JNK–p53–caspase-3 signaling cascade. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1226-8453 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1226845315000676; https://doaj.org/toc/1226-8453 |
| DOI: |
10.1016/j.jgr.2015.06.006 |
| URL الوصول: |
https://doaj.org/article/1def127bfad1422ab91c119f8b9d91ba |
| رقم الانضمام: |
edsdoj.1def127bfad1422ab91c119f8b9d91ba |
| قاعدة البيانات: |
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