التفاصيل البيبلوغرافية
| العنوان: |
Telomere Dysfunction in Oocytes and Embryos From Obese Mice |
| المؤلفون: |
Juan Ge, Congyang Li, Hongzheng Sun, Yongan Xin, Shuai Zhu, Yuan Liu, Shoubin Tang, Longsen Han, Zhenyue Huang, Qiang Wang |
| المصدر: |
Frontiers in Cell and Developmental Biology, Vol 9 (2021) |
| بيانات النشر: |
Frontiers Media S.A., 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
obesity, oocyte, embryo, telomere, reproduction, Biology (General), QH301-705.5 |
| الوصف: |
Maternal obesity impairs oocyte quality and embryo development. However, the potential molecular pathways remain to be explored. In the present study, we examined the effects of obesity on telomere status in oocytes and embryos obtained from mice fed with high-fat diet (HFD). Of note, telomere shortening was observed in both oocytes and early embryos from obese mice, as evidenced by the reduced expression of telomerase reverse transcriptase and activity of telomerase. Moreover, quantitative analysis of telomere dysfunction-induced foci (TIFs) revealed that maternal obesity induces the defective telomeres in oocytes and embryos. Meanwhile, the high frequency of aneuploidy was detected in HFD oocytes and embryos as compared to controls, accompanying with the increased incidence of apoptotic blastocysts. In conclusion, these results indicate that telomere dysfunction might be a molecular pathway mediating the effects of maternal obesity on oocyte quality and embryo development. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-634X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fcell.2021.617225/full; https://doaj.org/toc/2296-634X |
| DOI: |
10.3389/fcell.2021.617225 |
| URL الوصول: |
https://doaj.org/article/1d459296fba14eebbbaf9767659b06d4 |
| رقم الانضمام: |
edsdoj.1d459296fba14eebbbaf9767659b06d4 |
| قاعدة البيانات: |
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