التفاصيل البيبلوغرافية
| العنوان: |
Disease Modifying Monoclonal Antibodies and Symptomatic Pharmacological Treatment for Alzheimer’s Disease |
| المؤلفون: |
Xiaoming Qi, Damir Nizamutdinov, Song Stephen Yi, Erxi Wu, Jason H. Huang |
| المصدر: |
Biomedicines, Vol 12, Iss 11, p 2636 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
Alzheimer’s disease, amyloid beta, monoclonal antibodies, aducanumab, lecanemab, donanemab, Biology (General), QH301-705.5 |
| الوصف: |
Alzheimer’s Disease (AD) is an irreversible, progressive syndrome characterized by neurocognitive impairment. Two neuropathological features seen in AD are extracellular amyloid plaques consisting of amyloid beta1-40 and 1-42, and intracellular neurofibrillary tangles (NFTs). For decades, neuroscience research has heavily focused on seeking to understand the primary mechanism of AD and searching for pharmacological approaches for the treatment of dementia. Three monoclonal antibodies that act against amyloid beta—aducanumab, lecanemab, and donanemab—have been approved by the Food and Drug Administration (FDA) for the treatment of mild cognitive impairment and mild AD, in addition to medications for cognitive symptom management such as acetylcholinesterase inhibitors and the N-methyl-D-aspartate (NMDA) antagonist. Further trials should focus on the combination of therapies targeting amyloid plaques and tau pathology. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2227-9059 |
| Relation: |
https://www.mdpi.com/2227-9059/12/11/2636; https://doaj.org/toc/2227-9059 |
| DOI: |
10.3390/biomedicines12112636 |
| URL الوصول: |
https://doaj.org/article/1d2426fcd5374860861aee3020452027 |
| رقم الانضمام: |
edsdoj.1d2426fcd5374860861aee3020452027 |
| قاعدة البيانات: |
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