التفاصيل البيبلوغرافية
| العنوان: |
Individual serum saturated fatty acids and markers of chronic subclinical inflammation: the Insulin Resistance Atherosclerosis Study |
| المؤلفون: |
Ingrid D. Santaren, Steven M. Watkins, Angela D. Liese, Lynne E. Wagenknecht, Marian J. Rewers, Steven M. Haffner, Carlos Lorenzo, Andreas Festa, Richard P. Bazinet, Anthony J. Hanley |
| المصدر: |
Journal of Lipid Research, Vol 58, Iss 11, Pp 2171-2179 (2017) |
| بيانات النشر: |
Elsevier, 2017. |
| سنة النشر: |
2017 |
| المجموعة: |
LCC:Biochemistry |
| مصطلحات موضوعية: |
metabolic disease, epidemiology, diet and dietary lipids, cohort study, Biochemistry, QD415-436 |
| الوصف: |
Recent evidence has documented distinct effects of individual saturated FAs (SFAs) on cardiometabolic outcomes, with potential protective effects from odd- and very long-chain SFAs (VLSFAs). Cross-sectional and prospective associations of individual serum SFAs (12:0, 14:0, 15:0, 16:0, 18:0, 20:0, 22:0, and total SFA) with proinflammatory biomarkers and adiponectin were investigated in 555 adults from the IRAS. Principal component analysis (PCA) of proinflammatory markers yielded three clusters: principal component (PC) 1: fibrinogen, white cell count, C-reactive protein; PC 2: plasminogen activator inhibitor-1 (PAI-1), TNF-α, IL-18; PC 3: IL-6 and IL-8. Cross-sectional analyses on proinflammatory PCs and adiponectin, and prospective analyses on 5 year PAI-1 and fibrinogen concentrations were conducted with multiple regression. Total SFA and 16:0 were positively associated with PC 1 and PC 2, and negatively associated with adiponectin. The 14:0 was positively associated with PC 1 and negatively associated with adiponectin. In contrast, 15:0, 20:0, and 22:0 were negatively associated with PC 2, and 20:0 and 22:0 were positively associated with adiponectin. The 18:0 was negatively associated with PC 3. Prospectively, 15:0, 18:0, 20:0, and 22:0 were negatively associated with 5 year PAI-1 concentrations. The results demonstrate that individual SFAs have distinct roles in subclinical inflammation, highlighting the unique metabolic impacts of individual SFAs. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
0022-2275 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0022227520338074; https://doaj.org/toc/0022-2275 |
| DOI: |
10.1194/jlr.P076836 |
| URL الوصول: |
https://doaj.org/article/a1d1cb75120a49e0b67fdcc64393e974 |
| رقم الانضمام: |
edsdoj.1d1cb75120a49e0b67fdcc64393e974 |
| قاعدة البيانات: |
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