التفاصيل البيبلوغرافية
| العنوان: |
Predictors of pulmonary sequelae after COVID-19 pneumonia: A 12-month follow-up study |
| المؤلفون: |
Nicol Bernardinello, Elisabetta Cocconcelli, Chiara Giraudo, Matteo Daverio, Gioele Castelli, Simone Petrarulo, Matteo Bovo, Giulia Fichera, Silvia Cavinato, Anna Maria Cattelan, Marina Saetta, Paolo Spagnolo, Elisabetta Balestro |
| المصدر: |
Frontiers in Medicine, Vol 10 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
COVID-19, pulmonary fibrosis, 12-month follow-up, CT scan, SARS-CoV-2, Medicine (General), R5-920 |
| الوصف: |
BackgroundSince the beginning of the SARS-CoV-2 pandemic, over 550 million people have been infected worldwide. Despite these large numbers, the long-term pulmonary consequences of COVID-19 remain unclear.AimsThe aim of this single-center observational cohort study was to identify and characterize pulmonary sequelae of COVID-19 at 12 months from hospitalization and to reveal possible predictors for the persistence of long-term lung consequences.MethodsBased on the persistence or absence of radiological changes after 12 months from hospitalization, the whole population was categorized into NOT-RECOVERED (NOT-REC) and RECOVERED (REC) groups, respectively. Clinical and pulmonary function data tests and clinical data were also collected and compared in the two groups. In the NOT-REC group, high resolution computed tomography (HRCT) images were semiquantitatively scored analyzing ground-glass opacities (GGO), interstitial thickening (IT), consolidations (CO), linear and curvilinear band opacities, and bronchiectasis for each lung lobe. Logistic regression analyses served to detect the factors associated with 12-month radiological consequences.ResultsOut of the 421 patients followed after hospitalization for SARS-CoV-2 pneumonia, 347 met inclusion and exclusion criteria and were enrolled in the study. The NOT-REC patients (n = 24; 6.9%) were significantly older [67 (62–76) years vs. 63 (53–71) years; p = 0.02], more frequently current smokers [4 (17%) vs. 12 (4%); p = 0.02], and with more severe respiratory failure at the time of hospitalization [PaO2/FiO2 at admission: 201 (101–314) vs. 295 (223–343); p = 0.01] compared to REC group (n = 323; 93.1%). On multivariable analysis, being a current smoker resulted in an independent predictor for lung sequelae after 12 months from hospitalization [5.6 OR; 95% CI (1.41–22.12); p = 0.01].ConclusionAfter 12 months from hospital admission, a limited number of patients displayed persistent pulmonary sequelae with minimal extension. Being a current smoker at the time of SARS-CoV-2 infection is an independent predictive factor to lung consequences, regardless of the disease severity. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2023.1084002/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2023.1084002 |
| URL الوصول: |
https://doaj.org/article/1c8511523e5a4f6595e17ab92a4c3b4a |
| رقم الانضمام: |
edsdoj.1c8511523e5a4f6595e17ab92a4c3b4a |
| قاعدة البيانات: |
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