Academic Journal
Specific labeling of synaptic schwann cells reveals unique cellular and molecular features
| العنوان: | Specific labeling of synaptic schwann cells reveals unique cellular and molecular features |
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| المؤلفون: | Ryan Castro, Thomas Taetzsch, Sydney K Vaughan, Kerilyn Godbe, John Chappell, Robert E Settlage, Gregorio Valdez |
| المصدر: | eLife, Vol 9 (2020) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | perisynaptic schwann cells, terminal schwann cells, NMJ, automated perimetrycytes, synaptic glia, astrocytes, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Perisynaptic Schwann cells (PSCs) are specialized, non-myelinating, synaptic glia of the neuromuscular junction (NMJ), that participate in synapse development, function, maintenance, and repair. The study of PSCs has relied on an anatomy-based approach, as the identities of cell-specific PSC molecular markers have remained elusive. This limited approach has precluded our ability to isolate and genetically manipulate PSCs in a cell specific manner. We have identified neuron-glia antigen 2 (NG2) as a unique molecular marker of S100β+ PSCs in skeletal muscle. NG2 is expressed in Schwann cells already associated with the NMJ, indicating that it is a marker of differentiated PSCs. Using a newly generated transgenic mouse in which PSCs are specifically labeled, we show that PSCs have a unique molecular signature that includes genes known to play critical roles in PSCs and synapses. These findings will serve as a springboard for revealing drivers of PSC differentiation and function. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/56935; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.56935 |
| URL الوصول: | https://doaj.org/article/1be4c178b8f042e7815c81916532d5f5 |
| رقم الانضمام: | edsdoj.1be4c178b8f042e7815c81916532d5f5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.56935 |