التفاصيل البيبلوغرافية
| العنوان: |
A Novel Approach of Antiviral Drugs Targeting Viral Genomes |
| المؤلفون: |
Phuong Thi Hoang, Quynh Xuan Thi Luong, Ramadhani Qurrota Ayun, Yongjun Lee, Thuy Thi Bich Vo, Taehyun Kim, Sukchan Lee |
| المصدر: |
Microorganisms, Vol 10, Iss 8, p 1552 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
viral disease, viral genome degradation, broad-spectrum antiviral drugs, 3D8 scFv, ISGs, CRISPR/Cas, Biology (General), QH301-705.5 |
| الوصف: |
Outbreaks of viral diseases, which cause morbidity and mortality in animals and humans, are increasing annually worldwide. Vaccines, antiviral drugs, and antibody therapeutics are the most effective tools for combating viral infection. The ongoing coronavirus disease 2019 pandemic, in particular, raises an urgent need for the development of rapid and broad-spectrum therapeutics. Current antiviral drugs and antiviral antibodies, which are mostly specific at protein levels, have encountered difficulties because the rapid evolution of mutant viral strains resulted in drug resistance. Therefore, degrading viral genomes is considered a novel approach for developing antiviral drugs. The current article highlights all potent candidates that exhibit antiviral activity by digesting viral genomes such as RNases, RNA interference, interferon-stimulated genes 20, and CRISPR/Cas systems. Besides that, we introduce a potential single-chain variable fragment (scFv) that presents antiviral activity against various DNA and RNA viruses due to its unique nucleic acid hydrolyzing characteristic, promoting it as a promising candidate for broad-spectrum antiviral therapeutics. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-2607 |
| Relation: |
https://www.mdpi.com/2076-2607/10/8/1552; https://doaj.org/toc/2076-2607 |
| DOI: |
10.3390/microorganisms10081552 |
| URL الوصول: |
https://doaj.org/article/1bc9743b36f3490886f928aae1d0a20f |
| رقم الانضمام: |
edsdoj.1bc9743b36f3490886f928aae1d0a20f |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder