التفاصيل البيبلوغرافية
| العنوان: |
Spatiotemporal scaling changes in gait in a progressive model of Parkinson's disease |
| المؤلفون: |
Alex M. Doyle, Devyn Bauer, Claudia Hendrix, Ying Yu, Shane D. Nebeck, Sinta Fergus, Jordan Krieg, Lucius K. Wilmerding, Madeline Blumenfeld, Emily Lecy, Chelsea Spencer, Ziling Luo, Disa Sullivan, Krista Brackman, Dylan Ross, Sendréa Best, Ajay Verma, Tyler Havel, Jing Wang, Luke Johnson, Jerrold L. Vitek, Matthew D. Johnson |
| المصدر: |
Frontiers in Neurology, Vol 13 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: |
Parkinson's disease, gait, MPTP, non-human primate, pressure walkway, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: |
ObjectiveGait dysfunction is one of the most difficult motor signs to treat in patients with Parkinson's disease (PD). Understanding its pathophysiology and developing more effective therapies for parkinsonian gait dysfunction will require preclinical studies that can quantitatively and objectively assess the spatial and temporal features of gait.DesignWe developed a novel system for measuring volitional, naturalistic gait patterns in non-human primates, and then applied the approach to characterize the progression of parkinsonian gait dysfunction across a sequence of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatments that allowed for intrasubject comparisons across mild, moderate, and severe stages.ResultsParkinsonian gait dysfunction was characterized across treatment levels by a slower stride speed, increased time in both the stance and swing phase of the stride cycle, and decreased cadence that progressively worsened with overall parkinsonian severity. In contrast, decreased stride length occurred most notably in the moderate to severe parkinsonian state.ConclusionThe results suggest that mild parkinsonism in the primate model of PD starts with temporal gait deficits, whereas spatial gait deficits manifest after reaching a more severe parkinsonian state overall. This study provides important context for preclinical studies in non-human primates studying the neurophysiology of and treatments for parkinsonian gait. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-2295 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fneur.2022.1041934/full; https://doaj.org/toc/1664-2295 |
| DOI: |
10.3389/fneur.2022.1041934 |
| URL الوصول: |
https://doaj.org/article/1b8288cfed764f0c8385c037d03fc652 |
| رقم الانضمام: |
edsdoj.1b8288cfed764f0c8385c037d03fc652 |
| قاعدة البيانات: |
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