Academic Journal
STUDY MOLECULES DOCKING OF ALKALOIDS IN KRATOM ON SEROTONIN TRANSPORTER (SERT), NOREPINEPHRINE TRANSPORTER (NET), AND MONOAMINE OXIDASE (MAO)
| العنوان: | STUDY MOLECULES DOCKING OF ALKALOIDS IN KRATOM ON SEROTONIN TRANSPORTER (SERT), NOREPINEPHRINE TRANSPORTER (NET), AND MONOAMINE OXIDASE (MAO) |
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| المؤلفون: | Dandi Irawan, Bambang Wijianto, Harianto IH |
| المصدر: | Jurnal Kimia Riset, Vol 8, Iss 2, Pp 200-219 (2023) |
| بيانات النشر: | Universitas Airlangga, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | alkaloid, depression, docking study, mao, net, sert, Chemistry, QD1-999 |
| الوصف: | Kratom (Mitragyna speciosa Korth) is a tropical plant originating from Southeast Asia that predominantly contains alkaloid compounds and can potentially maintain levels of monoamine compounds in the body to treat depression. The study aimed to examine the potential of 8 alkaloid compounds in kratom as antidepressants towards four target proteins: Serotonin Transporter (SERT), Dopamine Transporter (DOPAT), Leucine Transporter (LEUT), and Monoamine Oxidase (MAO) via molecular docking. The Pyrx program is used with exhaustiveness 106 as the protocol, and the grid is adapted to the active site of each receptor. The affinity values of the alkaloid compounds in kratom are mitragynine, 7-hydroxy mitragynine, speciociliatine, paynantheine, speciogynine, corynantheidine, mitraciliatine, and 9-hydroxycorynantheidine, for MAO were -7.1, -6.1, -5.7, -6.7, -5.7, -7.7, -5.7, and -5.7 kcal/ mole. All compounds bind to amino acid residues in the target protein through hydrogen and pi (π) bonds. All the tested alkaloid compounds have the potential to be re-uptake inhibitors SERT, DOPAT, LEUT, and Monoamine Oxidase (MAO). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Indonesian |
| تدمد: | 2528-0414 2528-0422 |
| Relation: | https://e-journal.unair.ac.id/JKR/article/view/50785; https://doaj.org/toc/2528-0414; https://doaj.org/toc/2528-0422 |
| DOI: | 10.20473/jkr.v8i2.50785 |
| URL الوصول: | https://doaj.org/article/1b81186b077f47d0a685f8ec1d13c112 |
| رقم الانضمام: | edsdoj.1b81186b077f47d0a685f8ec1d13c112 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 25280414 25280422 |
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| DOI: | 10.20473/jkr.v8i2.50785 |