Academic Journal
Do phosphatase of regenerating liver-3, matrix metalloproteinases-2, matrix metalloproteinases-9, and epidermal growth factor receptor-1 predict response to therapy and survival in glioblastoma multiforme?
| العنوان: | Do phosphatase of regenerating liver-3, matrix metalloproteinases-2, matrix metalloproteinases-9, and epidermal growth factor receptor-1 predict response to therapy and survival in glioblastoma multiforme? |
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| المؤلفون: | Priyanka Soni, Nuzhat Husain, Anil Chandra, Bal Krishan Ojha, Madan Lal Brahma Bhatt, Rakesh Kumar Gupta |
| المصدر: | Indian Journal of Pathology and Microbiology, Vol 59, Iss 3, Pp 287-293 (2016) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Pathology LCC:Microbiology |
| مصطلحات موضوعية: | Epidermal growth factor receptor, glioblastoma multiforme, immunohistochemistry, matrix metalloproteinases, phosphatase of regenerating liver, Pathology, RB1-214, Microbiology, QR1-502 |
| الوصف: | Context: Poor survival of the glioblastoma multiforme (GBM) has been attributed in part to the invasive nature of the lesion making complete surgical removal near impossible. Phosphatase of regenerating liver-3 (PRL-3), matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9), and epidermal growth factor receptor (EGFR-1) play a role in invasive nature of tumor cells. Aims: This study was conducted to evaluate PRL-3, MMP-2, MMP-9, and EGFR-1 (markers) expression in cases to GBM and to correlate their expression with therapy response and survival. Settings and Design: GBM cases (n = 62) underwent surgery followed by radiation (n = 34) and chemoradiation (n = 28). Using WHO Response Evaluation Criteria in Solid Tumors criteria response to therapy was assessed at 3 months and cases followed up for survival. Subjects and Methods: Expression of markers was assessed by immunohistochemistry as a percentage of positive tumor cells in hot spots. Statistical Analysis Used: Kaplan–Meier, ANOVA, Chi-square test, univariate, and multivariate Cox-regression analysis was done. Results: Response to therapy was evident in 54.8% cases of responders with the mean survival of 494.03 ± 201.13 days and 45.2% cases of non responders (278.32 ± 121.66 days) with P = 0.001. Mean survival for the patient's opted chemoradiation was 457.43 ± 222.48 days which was approximately 3 months greater than those who opted radiation alone (P = 0.029). We found PRL-3 overexpression was an independent, significant, poor prognostic factor for survival by multivariate analysis (P = 0.044). Cases negative for MMP's and EGFR showed increased survival, but the difference was insignificant. Conclusion: PRL-3 expression appears to be related to an adverse disease outcome. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0377-4929 |
| Relation: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2016;volume=59;issue=3;spage=287;epage=293;aulast=Soni; https://doaj.org/toc/0377-4929 |
| DOI: | 10.4103/0377-4929.188121 |
| URL الوصول: | https://doaj.org/article/1b3b248ae4a4415b811b20ef8565c77a |
| رقم الانضمام: | edsdoj.1b3b248ae4a4415b811b20ef8565c77a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03774929 |
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| DOI: | 10.4103/0377-4929.188121 |