Academic Journal
Ferulic acid ameliorated placental inflammation and apoptosis in rat with preeclampsia
| العنوان: | Ferulic acid ameliorated placental inflammation and apoptosis in rat with preeclampsia |
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| المؤلفون: | Yuanyuan Chen, Fengxia Xue, Cha Han, Huiyun Yang, Lulu Han, Ke Li, Jie Li, Qian Xu, Zengyan Li, Bibo Yuan, Limin Yu, Xiaoli Gao, Ye Yan |
| المصدر: | Clinical and Experimental Hypertension, Vol 41, Iss 6, Pp 524-530 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | ferulic acid, placental inflammation, apoptpsis, preeclampsia, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Preeclampsia (PE) occurs specifically during pregnancy characterized by new-onset hypertension. The pathogenesis of PE was complicated, and inflammation may be central to the pathogenesis of PE. Ferulic acid (FA) is recognized to prevent cell damage and apoptosis induced by oxidative stress and inflammation. In our study, we used NG-nitro-l-arginine methyl ester (L-NAME)-induced rat model of PE to investigate whether FA improved PE and its possible mechanism. We found that FA significantly reduced blood pressure, urine volume, and urinary protein level in rats with PE. Meanwhile, FA decreased L-NAME induced higher expression of circulating TNF-α、IL-6、IL-1β and PlGF, it reduced placental TNF-α and NF-κB p65. Furthermore, FA rescued L-NAME induced decreasing expression of IL-4 and IL-10 expression in the circulation and placenta of rats. FA also ameliorated placental apoptosis in L-NAME induced rats by increasing Bcl-2 whereas decreasing Bax expression in placenta. It suggested FA as a potential candidate for the treatment of various disorders including L-NAME induced preeclampsia in rats through decreasing placental inflammation and apoptosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1064-1963 1525-6006 10641963 |
| Relation: | https://doaj.org/toc/1064-1963; https://doaj.org/toc/1525-6006 |
| DOI: | 10.1080/10641963.2018.1516773 |
| URL الوصول: | https://doaj.org/article/1abab208d2a741b1b3adb57e55ebc4b9 |
| رقم الانضمام: | edsdoj.1abab208d2a741b1b3adb57e55ebc4b9 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 10641963 15256006 |
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| DOI: | 10.1080/10641963.2018.1516773 |