التفاصيل البيبلوغرافية
| العنوان: |
Can proline dehydrogenase—a key enzyme involved in proline metabolism—be a novel target for cancer therapy? |
| المؤلفون: |
Xiangyuan Xu, Guangtao Zhang, Yijia Chen, Weina Xu, Yujing Liu, Guang Ji, Hanchen Xu |
| المصدر: |
Frontiers in Oncology, Vol 13 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
ProDH, proline metabolism, cancer therapy, cancer metabolism, immunosuppression, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Emerging evidence suggests that proline metabolism is important for regulating the survival and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme catalyzing proline catabolism, and the degradation products of proline by PRODH, such as ATP and ROS, are known to play critical roles in cancer progression. Notably, the role of PRODH in cancer is still complicated and unclear, and primarily depends on the cancer type and tumor microenvironment. For instance, PRODH induces apoptosis and senescence through ROS signaling in different types of cancers, while as a protumor factor, PRODH promotes malignant phenotypes of certain tumors under stresses such as hypoxia. In order to assess whether PRODH can serve as a novel target for cancer therapy, we will provide an overview of the biological functions of PRODH and its double-edged role in cancer in this article. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2023.1254439/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2023.1254439 |
| URL الوصول: |
https://doaj.org/article/1aaef2d6e3d94ee0a33323d63683a9f3 |
| رقم الانضمام: |
edsdoj.1aaef2d6e3d94ee0a33323d63683a9f3 |
| قاعدة البيانات: |
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