Academic Journal
Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer
| العنوان: | Incidental Statin Use and the Risk of Stroke or Transient Ischemic Attack after Radiotherapy for Head and Neck Cancer |
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| المؤلفون: | Daniel Addison, Patrick R. Lawler, Hamed Emami, Sumbal A. Janjua, Pedro V. Staziaki, Travis R. Hallett, Orla Hennessy, Hang Lee, Bálint Szilveszter, Michael Lu, Negar Mousavi, Matthew G. Nayor, Francesca N. Delling, Javier M. Romero, Lori J. Wirth, Annie W. Chan, Udo Hoffmann, Tomas G. Neilan |
| المصدر: | Journal of Stroke, Vol 20, Iss 1, Pp 71-79 (2018) |
| بيانات النشر: | Korean Stroke Society, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | radiation, radiotherapy, hydroxymethylglutaryl-coa reductase inhibitors, cerebrovascular events, stroke, ischemic attack, transient, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Background and Purpose Interventions to reduce the risk for cerebrovascular events (CVE; stroke and transient ischemic attack [TIA]) after radiotherapy (RT) for head and neck cancer (HNCA) are needed. Among broad populations, statins reduce CVEs; however, whether statins reduce CVEs after RT for HNCA is unclear. Therefore, we aimed to test whether incidental statin use at the time of RT is associated with a lower rate of CVEs after RT for HNCA. Methods From an institutional database we identified all consecutive subjects treated with neck RT from 2002 to 2012 for HNCA. Data collection and event adjudication was performed by blinded teams. The primary outcome was a composite of ischemic stroke and TIA. The secondary outcome was ischemic stroke. The association between statin use and events was determined using Cox proportional hazard models after adjustment for traditional and RT-specific risk factors. Results The final cohort consisted of 1,011 patients (59±13 years, 30% female, 44% hypertension) with 288 (28%) on statins. Over a median follow-up of 3.4 years (interquartile range, 0.1 to 14) there were 102 CVEs (89 ischemic strokes and 13 TIAs) with 17 in statin users versus 85 in nonstatins users. In a multivariable model containing known predictors of CVE, statins were associated with a reduction in the combination of stroke and TIA (hazard ratio [HR], 0.4; 95% confidence interval [CI], 0.2 to 0.8; P=0.01) and ischemic stroke alone (HR, 0.4; 95% CI, 0.2 to 0.8; P=0.01). Conclusions Incidental statin use at the time of RT for HNCA is associated with a lower risk of stroke or TIA. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2287-6391 2287-6405 |
| Relation: | http://www.j-stroke.org/upload/pdf/jos-2017-01802.pdf; https://doaj.org/toc/2287-6391; https://doaj.org/toc/2287-6405 |
| DOI: | 10.5853/jos.2017.01802 |
| URL الوصول: | https://doaj.org/article/1a99b400631a4a8aba97ff2cbf02bfad |
| رقم الانضمام: | edsdoj.1a99b400631a4a8aba97ff2cbf02bfad |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22876391 22876405 |
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| DOI: | 10.5853/jos.2017.01802 |