التفاصيل البيبلوغرافية
| العنوان: |
Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development |
| المؤلفون: |
Kanako Matsumoto, Yuki Akieda, Yukinari Haraoka, Naoki Hirono, Hiroshi Sasaki, Tohru Ishitani |
| المصدر: |
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024) |
| بيانات النشر: |
Nature Portfolio, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Abstract Unfit cells with defective signalling or gene expression are eliminated through competition with neighbouring cells. However, physiological roles and mechanisms of cell competition in vertebrates remain unclear. In addition, universal mechanisms regulating diverse cell competition are unknown. Using zebrafish imaging, we reveal that cell competition ensures robust patterning of the spinal cord and muscle through elimination of cells with unfit sonic hedgehog activity, driven by cadherin-mediated communication between unfit and neighbouring fit cells and subsequent activation of the Smad-Foxo3-reactive oxygen species axis. We identify Foxo3 as a common marker of loser cells in various types of cell competition in zebrafish and mice. Foxo3-mediated physiological cell competition is required for eliminating various naturally generated unfit cells and for the consequent precise patterning during zebrafish embryogenesis and organogenesis. Given the implication of Foxo3 downregulation in age-related diseases, cell competition may be a defence system to prevent abnormalities throughout development and adult homeostasis. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-024-55108-x |
| URL الوصول: |
https://doaj.org/article/1a3078705b48433e9907be7a0aa9325c |
| رقم الانضمام: |
edsdoj.1a3078705b48433e9907be7a0aa9325c |
| قاعدة البيانات: |
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