التفاصيل البيبلوغرافية
| العنوان: |
Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence |
| المؤلفون: |
Sarkis Sarkis, Veronica Galli, Ramona Moles, David Yurick, Georges Khoury, Damian F. J. Purcell, Genoveffa Franchini, Cynthia A. Pise-Masison |
| المصدر: |
Retrovirology, Vol 16, Iss 1, Pp 1-14 (2019) |
| بيانات النشر: |
BMC, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
HTLV-1, STLV-1, orf-I, p12/p8, rex-orf-I, Adult T-cell leukemia/lymphoma, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
Abstract The human T cell leukemia virus type 1 (HTVL-1), first reported in 1980 by Robert Gallo’s group, is the etiologic agent of both cancer and inflammatory diseases. Despite approximately 40 years of investigation, the prognosis for afflicted patients remains poor with no effective treatments. The virus persists in the infected host by evading the host immune response and inducing proliferation of infected CD4+ T-cells. Here, we will review the role that viral orf-I protein products play in altering intracellular signaling, protein expression and cell–cell communication in order to escape immune recognition and promote T-cell proliferation. We will also review studies of orf-I mutations found in infected patients and their potential impact on viral load, transmission and persistence. Finally, we will compare the orf-I gene in HTLV-1 subtypes as well as related STLV-1. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1742-4690 |
| Relation: |
https://doaj.org/toc/1742-4690 |
| DOI: |
10.1186/s12977-019-0502-1 |
| URL الوصول: |
https://doaj.org/article/1a26ed6d6b764de89805abf12f4b8935 |
| رقم الانضمام: |
edsdoj.1a26ed6d6b764de89805abf12f4b8935 |
| قاعدة البيانات: |
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