التفاصيل البيبلوغرافية
| العنوان: |
Dipeptidyl Peptidase 4/Midline‐1 Axis Promotes T Lymphocyte Motility in Atherosclerosis |
| المؤلفون: |
Xiaoquan Rao, Michael Razavi, Georgeta Mihai, Yingying Wei, Zachary Braunstein, Matthew B. Frieman, Xiao Jian Sun, Quan Gong, Jun Chen, Gang Zhao, Zheng Liu, Michael J. Quon, Lingli Dong, Sanjay Rajagopalan, Jixin Zhong |
| المصدر: |
Advanced Science, Vol 10, Iss 9, Pp n/a-n/a (2023) |
| بيانات النشر: |
Wiley, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
atherosclerosis, dipeptidyl peptidase‐4, midline‐1, migration, T cell, Science |
| الوصف: |
Abstract T cells play a crucial role in atherosclerosis, with its infiltration preceding the formation of atheroma. However, how T‐cell infiltration is regulated in atherosclerosis remains largely unknown. Here, this work demonstrates that dipeptidyl peptidase‐4 (DPP4) is a novel regulator of T‐cell motility in atherosclerosis. Single‐cell ribonucleic acid (RNA) sequencing and flow cytometry show that CD4+ T cells in atherosclerotic patients display a marked increase of DPP4. Lack of DPP4 in hematopoietic cells or T cells reduces T‐cell infiltration and atherosclerotic plaque volume in atherosclerosis mouse models. Mechanistically, DPP4 deficiency reduces T‐cell motility by suppressing the expression of microtubule associated protein midline‐1 (Mid1) in T cells. Deletion of either DPP4 or Mid1 inhibits chemokine‐induced shape change and motility, while restitution of Mid1 in Dpp4−/− T cell largely restores its migratory ability. Thus, DPP4/Mid1, as a novel regulator of T‐cell motility, may be a potential inflammatory target in atherosclerosis. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2198-3844 |
| Relation: |
https://doaj.org/toc/2198-3844 |
| DOI: |
10.1002/advs.202204194 |
| URL الوصول: |
https://doaj.org/article/1a03d47b9fa342238ccecd0a4c5e5f9b |
| رقم الانضمام: |
edsdoj.1a03d47b9fa342238ccecd0a4c5e5f9b |
| قاعدة البيانات: |
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