التفاصيل البيبلوغرافية
| العنوان: |
Lower In vivo Myo-Inositol in the Anterior Cingulate Cortex Correlates with Delayed Melatonin Rhythms in Young Persons with Depression |
| المؤلفون: |
Rébecca Robillard, Jim Lagopoulos, Daniel F. Hermens, Sharon L. Naismith, Naomi L. Rogers, Django White, Joanne S. Carpenter, Manreena Kaur, Elizabeth M. Scott, Ian B. Hickie |
| المصدر: |
Frontiers in Neuroscience, Vol 11 (2017) |
| بيانات النشر: |
Frontiers Media S.A., 2017. |
| سنة النشر: |
2017 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
melatonin, depression, magnetic resonance spectroscopy, myo-inositol, circadian, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Myo-inositol, a second messenger glucose isomer and glial marker, is potentiated by melatonin. In addition to common abnormalities in melatonin regulation, depressive disorders have been associated with reduced myo-inositol in frontal structures. This study examined associations between myo-inositol in the anterior cingulate cortex and the timing of evening melatonin release. Forty young persons with unipolar depression were recruited from specialized mental health services (20.3 ± 3.8 years old). Healthy controls were recruited from the community (21.7 ± 2.6 years old). The timing of dim light melatonin onset (DLMO) was estimated using salivary melatonin sampling. Myo-inositol concentrations (MI/CrPCr ratio) in the anterior cingulate cortex were obtained using proton magnetic resonance spectroscopy. After controlling for age, sex, and CrPCr concentration the depression group had significantly lower MI/CrPCr ratios than healthy controls [F(4, 75) = 11.4, p = 0.001]. In the depression group, later DLMO correlated with lower MI/CrPCr ratio (r = −0.48, p = 0.014). These findings suggest that neurochemical changes in the frontal cortex are associated with circadian disruptions in young persons with depression. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1662-453X |
| Relation: |
http://journal.frontiersin.org/article/10.3389/fnins.2017.00336/full; https://doaj.org/toc/1662-453X |
| DOI: |
10.3389/fnins.2017.00336 |
| URL الوصول: |
https://doaj.org/article/dc1a039246b441e5a3668b58c33aeaeb |
| رقم الانضمام: |
edsdoj.1a039246b441e5a3668b58c33aeaeb |
| قاعدة البيانات: |
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