Academic Journal
Temporal Changes in Phosphatidylserine Expression and Glucose Metabolism after Myocardial Infarction: An in Vivo Imaging Study in Mice
| العنوان: | Temporal Changes in Phosphatidylserine Expression and Glucose Metabolism after Myocardial Infarction: An in Vivo Imaging Study in Mice |
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| المؤلفون: | Sebastian Lehner, Andrei Todica, Stefan Brunner, Christopher Uebleis, Hao Wang, Carmen Wängler, Nadja Herbach, Tanja Herrler, Guido Böning, Rüdiger Paul Laubender, Paul Cumming, Ralf Schirrmacher, Wolfgang Franz, Marcus Hacker |
| المصدر: | Molecular Imaging, Vol 11 (2012) |
| بيانات النشر: | SAGE Publishing, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Biology (General) LCC:Medical technology |
| مصطلحات موضوعية: | Biology (General), QH301-705.5, Medical technology, R855-855.5 |
| الوصف: | Positron emission tomography (PET) for in vivo monitoring of phosphatidylserine externalization and glucose metabolism can potentially provide early predictors of outcome of cardioprotective therapies after myocardial infarction. We performed serial [ 68 Ga]annexin A5 PET (annexin-PET) and [ 18 F]fluorodeoxyglucose PET (FDG-PET) after myocardial infarction to determine the time of peak phosphatidylserine externalization in relation to impaired glucose metabolism in infracted tissue. Annexin- and FDG-PET recordings were obtained in female (C57BL6/N) mice on days 1 to 4 after ligation of the left anterior descending (LAD) artery. [ 68 Ga]annexin A5 uptake (%ID/g) in the LAD artery territory increased from 1.7 ± 1.1 on day 1 to 5.0 ± 3.3 on day 2 and then declined to 2.0 ± 1.4 on day 3 (p = .047 vs day 2) and 1.6 ± 1.4 on day 4 ( p = .014 vs day 2). These results matched apoptosis rates as estimated by autoradiography and fluorescein staining. FDG uptake (%ID/g) declined from 28 ± 14 on day 1 to 14 ± 3.5 on day 4 ( p < .0001 vs day 1). Whereas FDG-PET revealed continuous loss of cell viability after permanent LAD artery occlusion, annexin-PET indicated peak phosphatidylserine expression at day 2, which might be the optimal time point for therapy monitoring. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1536-0121 |
| Relation: | https://doaj.org/toc/1536-0121 |
| DOI: | 10.2310/7290.2012.00010 |
| URL الوصول: | https://doaj.org/article/19de5c48ffbc4313a9c8a56bb29d8634 |
| رقم الانضمام: | edsdoj.19de5c48ffbc4313a9c8a56bb29d8634 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 15360121 |
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| DOI: | 10.2310/7290.2012.00010 |