التفاصيل البيبلوغرافية
| العنوان: |
Conformational motions and ligand-binding underlying gating and regulation in IP3R channel |
| المؤلفون: |
Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David I. Yule, Irina I. Serysheva |
| المصدر: |
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022) |
| بيانات النشر: |
Nature Portfolio, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Here authors report cryo-EM structures of IP3R1 which provide atomic details of IP3, Ca2+ and ATP binding. Molecular motions of key domains and sidechains were found to regulate ligand binding and gating, which are validated by functional assays. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-34574-1 |
| URL الوصول: |
https://doaj.org/article/19978619640c40e4bd70b573581c08b9 |
| رقم الانضمام: |
edsdoj.19978619640c40e4bd70b573581c08b9 |
| قاعدة البيانات: |
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