Academic Journal
TRIM16 employs NRF2, ubiquitin system and aggrephagy for safe disposal of stress-induced misfolded proteins
| العنوان: | TRIM16 employs NRF2, ubiquitin system and aggrephagy for safe disposal of stress-induced misfolded proteins |
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| المؤلفون: | Kautilya Kumar Jena, Subhash Mehto, Srinivasa Prasad Kolapalli, Parej Nath, Swati Chauhan, Santosh Chauhan |
| المصدر: | Cell Stress, Vol 2, Iss 12, Pp 365-367 (2018) |
| بيانات النشر: | Shared Science Publishers OG, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | TRIM16, NRF2/NFE2L2, p62/SQSTM1, autophagy, protein aggregates, cancer, oxidative stress, protein homeostasis, protein quality control, aggrephagy, proteotoxic stress, Medicine, Biology (General), QH301-705.5 |
| الوصف: | The cellular stresses, genetic mutations, and environmental factors can critically affect the protein quality control checkpoints resulting in protein misfolding. Molecular chaperones play a crucial role in maintaining the healthy proteome by refolding the misfolded proteins into the native functional conformations. However, if they fail to refold the misfolded proteins into the native state, they are targeted by proteolytic systems for degradation. If the misfolded protein numbers increase more than what a cell can resolve, they get converted protein aggregates/inclusion bodies. The inclusion bodies are less cytotoxic than misfolded proteins. The enhanced production of misfolded proteins and protein aggregates are linked to several diseases collectively termed proteinopathies, which includes several neurodegenerative disorders. The understanding of molecular mechanisms that regulate the turnover of protein aggregates will pave path for therapeutic interventions of proteinopathies. In a recent report, we showed that a tripartite motif (TRIM) family protein, TRIM16 streamlines the process of protein aggregates turnover by regulating the NRF2-p62 axis and autophagy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2523-0204 |
| Relation: | http://www.cell-stress.com/researcharticles/2018a-jena-cell-stress/; https://doaj.org/toc/2523-0204 |
| URL الوصول: | https://doaj.org/article/196fb500c5504214aae3f0ddba0ba257 |
| رقم الانضمام: | edsdoj.196fb500c5504214aae3f0ddba0ba257 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25230204 |
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