Academic Journal
Association of miR-146a and miR196a2 genotype with susceptibility to idiopathic recurrent pregnancy loss in Iranian women: A case-control study
| العنوان: | Association of miR-146a and miR196a2 genotype with susceptibility to idiopathic recurrent pregnancy loss in Iranian women: A case-control study |
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| المؤلفون: | Emad Babakhanzadeh, Hamid Danaei, Mohammad Abedinzadeh, Hamid Reza Ashrafzadeh, Nasrin Ghasemi |
| المصدر: | International Journal of Reproductive BioMedicine, Vol 19, Iss 8, Pp 725-732 (2021) |
| بيانات النشر: | Shahid Sadoughi University of Medical Sciences, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Gynecology and obstetrics LCC:Reproduction |
| مصطلحات موضوعية: | rpl, mir-146a, mir196a2, polymorphism, rflp., Gynecology and obstetrics, RG1-991, Reproduction, QH471-489 |
| الوصف: | Abstract Background: Recurrent pregnancy loss (RPL) is the most common complaint of pregnancy in females with a prevalence of 5%. Numerous documents have shown that single nucleotide polymorphisms are able to change miRNA transcription and/or maturation, which may alter the incidence of disorders such as RPL. Objective: To assess the relationship of miR-146aC > G (rs2910164) and miR-196a2T > C (rs11614913) with RPL susceptibility in Iranian women. Materials and Methods: Blood samples were collected from 214 women who had experienced at least two consecutive spontaneous miscarriages (case) and 147 normal individuals without a history of miscarriage (control). MiR-146aC > G and miR-196a2T > C genotypes were evaluated via the restriction fragment length polymorphism technique. Results: The genotypes incidence did not show a significant difference in pre-miR-146aC > G polymorphism CC vs CG + GG (p = 0.854; OR = 0.933; 95% CI) and CC + CG vs GG (p = 0.282; OR = 1.454; 95% CI). Also, no significant difference was observed between pre-miR-196a2T > C polymorphism TT vs TC + CC (p = 0.862; OR = 0.938; 95% CI) and TT + TC vs CC and (p = 0.291; OR = 1.462; 95% CI) in both the case and control groups. Conclusion: The results showed that although the distribution of miR-146aC > G and miR-196a2T > C was different between the unknown RPL and control groups, these variances were not statistically significant. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2476-4108 2476-3772 |
| Relation: | https://doaj.org/toc/2476-4108; https://doaj.org/toc/2476-3772 |
| DOI: | 10.18502/ijrm.v19i8.9620 |
| URL الوصول: | https://doaj.org/article/aa193f6b49e947a0b85a29bc2bbbb56d |
| رقم الانضمام: | edsdoj.193f6b49e947a0b85a29bc2bbbb56d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24764108 24763772 |
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| DOI: | 10.18502/ijrm.v19i8.9620 |