التفاصيل البيبلوغرافية
| العنوان: |
Bridging the gap - estimation of 2022/2023 SARS-CoV-2 healthcare burden in Germany based on multidimensional data from a rapid epidemic panel |
| المؤلفون: |
Manuela Harries, Veronika K. Jaeger, Isti Rodiah, Max J. Hassenstein, Julia Ortmann, Maren Dreier, Isabell von Holt, Melanie Brinkmann, Alex Dulovic, Daniela Gornyk, Olga Hovardovska, Christina Kuczewski, Marc-André Kurosinski, Maike Schlotz, Nicole Schneiderhan-Marra, Monika Strengert, Gérard Krause, Martina Sester, Florian Klein, Astrid Petersmann, André Karch, Berit Lange |
| المصدر: |
International Journal of Infectious Diseases, Vol 139, Iss , Pp 50-58 (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: |
SARS-CoV-2, SEIR, ODE Model, IGRA, Humoral immunity, Scenarios, Infectious and parasitic diseases, RC109-216 |
| الوصف: |
Objectives: Throughout the SARS-CoV-2 pandemic, Germany like other countries lacked adaptive population-based panels to monitor the spread of epidemic diseases. Methods: To fill a gap in population-based estimates needed for winter 2022/23 we resampled in the German SARS-CoV-2 cohort study MuSPAD in mid-2022, including characterization of systemic cellular and humoral immune responses by interferon-γ-release assay (IGRA) and CLIA/IVN assay. We were able to confirm categorization of our study population into four groups with differing protection levels against severe COVID-19 courses based on literature synthesis. Using these estimates, we assessed potential healthcare burden for winter 2022/23 in different scenarios with varying assumptions on transmissibility, pathogenicity, new variants, and vaccine booster campaigns in ordinary differential equation models. Results: We included 9921 participants from eight German regions. While 85% of individuals were located in one of the two highest protection categories, hospitalization estimates from scenario modeling were highly dependent on viral variant characteristics ranging from 30-300% compared to the 02/2021 peak. Our results were openly communicated and published to an epidemic panel network and a newly established modeling network. Conclusions: We demonstrate feasibility of a rapid epidemic panel to provide complex immune protection levels for inclusion in dynamic disease burden modeling scenarios. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1201971223007762; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2023.11.014 |
| URL الوصول: |
https://doaj.org/article/1924d101aa3646c2888835726b894193 |
| رقم الانضمام: |
edsdoj.1924d101aa3646c2888835726b894193 |
| قاعدة البيانات: |
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