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Photoaging induced by long-term exposure to UV irradiation and amelioration by Skipjack tuna skin hydrolysates: Targeting inhibition of MAPK and NF-κB signaling hyperactivation

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العنوان: Photoaging induced by long-term exposure to UV irradiation and amelioration by Skipjack tuna skin hydrolysates: Targeting inhibition of MAPK and NF-κB signaling hyperactivation
المؤلفون: Defeng Xu, Mouming Zhao
المصدر: Journal of Functional Foods, Vol 98, Iss , Pp 105281- (2022)
بيانات النشر: Elsevier, 2022.
سنة النشر: 2022
المجموعة: LCC:Nutrition. Foods and food supply
مصطلحات موضوعية: Photoaging, Skipjack tuna hydrolysates, Oxidant stress, Inflammation, Cascading signaling pathways, Nutrition. Foods and food supply, TX341-641
الوصف: Excessive and long-term exposure of skin to UV irradiation induces the photoaging and previous reports have revealed the roles of oxidative stress and inflammation response in photoaging progression, which provides the potential targets for photoaging intervention. Herein, the low molecular weight hydrolysates obtained from Skipjack tuna skin (STH) were used to evaluate the ameliorating effects on photoaging and the action mechanism was further explored. Pathologically, STH significantly recovered the barrier functions and restored the impaired architectures of photoaging skin. Biochemically, the antioxidant capacity was remarkably elevated and the inflammatory cytokines were significantly reduced in photoaging skin when STH was simultaneously administrated. Moreover, the abnormalities in epidermal hyperplasia and dermal loss were dramatically improved, along with the significant increase of procollagen type Ⅰ expression and inhibition of MMP-1 activity (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1756-4646
Relation: http://www.sciencedirect.com/science/article/pii/S1756464622003516; https://doaj.org/toc/1756-4646
DOI: 10.1016/j.jff.2022.105281
URL الوصول: https://doaj.org/article/ace16d9834b3456093c6076ae0e567fd
رقم الانضمام: edsdoj.16d9834b3456093c6076ae0e567fd
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17564646
DOI:10.1016/j.jff.2022.105281