التفاصيل البيبلوغرافية
| العنوان: |
Toward Engineering Biosystems With Emergent Collective Functions |
| المؤلفون: |
Thomas E. Gorochowski, Sabine Hauert, Jan-Ulrich Kreft, Lucia Marucci, Namid R. Stillman, T.-Y. Dora Tang, Lucia Bandiera, Vittorio Bartoli, Daniel O. R. Dixon, Alex J. H. Fedorec, Harold Fellermann, Alexander G. Fletcher, Tim Foster, Luca Giuggioli, Antoni Matyjaszkiewicz, Scott McCormick, Sandra Montes Olivas, Jonathan Naylor, Ana Rubio Denniss, Daniel Ward |
| المصدر: |
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020) |
| بيانات النشر: |
Frontiers Media S.A., 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Biotechnology |
| مصطلحات موضوعية: |
synthetic biology, multi-agent modeling, systems biology, emergence, multi-scale, bioengineering, Biotechnology, TP248.13-248.65 |
| الوصف: |
Many complex behaviors in biological systems emerge from large populations of interacting molecules or cells, generating functions that go beyond the capabilities of the individual parts. Such collective phenomena are of great interest to bioengineers due to their robustness and scalability. However, engineering emergent collective functions is difficult because they arise as a consequence of complex multi-level feedback, which often spans many length-scales. Here, we present a perspective on how some of these challenges could be overcome by using multi-agent modeling as a design framework within synthetic biology. Using case studies covering the construction of synthetic ecologies to biological computation and synthetic cellularity, we show how multi-agent modeling can capture the core features of complex multi-scale systems and provide novel insights into the underlying mechanisms which guide emergent functionalities across scales. The ability to unravel design rules underpinning these behaviors offers a means to take synthetic biology beyond single molecules or cells and toward the creation of systems with functions that can only emerge from collectives at multiple scales. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-4185 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fbioe.2020.00705/full; https://doaj.org/toc/2296-4185 |
| DOI: |
10.3389/fbioe.2020.00705 |
| URL الوصول: |
https://doaj.org/article/1690bd498c644b809310d629489f45c1 |
| رقم الانضمام: |
edsdoj.1690bd498c644b809310d629489f45c1 |
| قاعدة البيانات: |
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