التفاصيل البيبلوغرافية
| العنوان: |
Distinct T-helper cell responses to Staphylococcus aureus bacteremia reflect immunologic comorbidities and correlate with mortality |
| المؤلفون: |
Jared A. Greenberg, Cara L. Hrusch, Mohammad R. Jaffery, Michael Z. David, Robert S. Daum, Jesse B. Hall, John P. Kress, Anne I. Sperling, Philip A. Verhoef |
| المصدر: |
Critical Care, Vol 22, Iss 1, Pp 1-13 (2018) |
| بيانات النشر: |
BMC, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Medical emergencies. Critical care. Intensive care. First aid |
| مصطلحات موضوعية: |
Sepsis, Staphylococcus aureus, Helper T cells, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| الوصف: |
Abstract Background The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood because these patients are often excluded from studies about septic immunity. The objectives of this study were to determine the immune response to a single pathogen (Staphylococcus aureus) among a diverse case mix of patients and to determine whether comorbidities affect immune and clinical outcomes. Methods Blood samples were drawn from 95 adult inpatients at multiple time points after the first positive S. aureus blood culture. Cox proportional hazards modeling was used to determine the associations between admission neutrophil counts, admission lymphocyte counts, cytokine levels, and 90-day mortality. A nested case-control flow cytometric analysis was conducted to determine T-helper type 1 (Th1), Th2, Th17, and regulatory T-cell (Treg) subsets among a subgroup of 28 patients. In a secondary analysis, we categorized patients as either having immunocompromising disorders (human immunodeficiency virus and hematologic malignancies), receiving immunosuppressive medications, or being not immunocompromised. Results Higher neutrophil-to-lymphocyte count ratios and higher Th17 cytokine responses relative to Th1 cytokine responses early after infection were independently associated with mortality and did not depend on the immune state of the patient (HR 1.93, 95% CI 1.17–3.17, p = 0.01; and HR 1.13, 95% CI 1.01–1.27, p = 0.03, respectively). On the basis of flow cytometric analysis of CD4 T-helper subsets, an increasing Th17/Treg response over the course of the infection was most strongly associated with increased mortality (HR 4.41, 95% CI 1.69–11.5, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1364-8535 |
| Relation: |
http://link.springer.com/article/10.1186/s13054-018-2025-x; https://doaj.org/toc/1364-8535 |
| DOI: |
10.1186/s13054-018-2025-x |
| URL الوصول: |
https://doaj.org/article/166e532703344a30aae61fea66aada77 |
| رقم الانضمام: |
edsdoj.166e532703344a30aae61fea66aada77 |
| قاعدة البيانات: |
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