Academic Journal
The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs
| العنوان: | The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs |
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| المؤلفون: | Shuo Yang, Hong Ma, Liang Wang, Fang Wang, Jiqiao Xia, Dongyu Liu, Linlin Mu, Xiuqin Yang, Di Liu |
| المصدر: | Cells, Vol 13, Iss 8, p 709 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | cold stress, piglets, ADRB3, beige adipocytes, thermogenesis, Cytology, QH573-671 |
| الوصف: | After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health. Although brown adipose tissue in rodents is primarily induced by β3-adrenergic receptor (ADRB3) stimulation, the activation of major β-adrenergic receptors (ADRBs) in pigs has been a topic of debate. To address this, we developed overexpression vectors for ADRB1, ADRB2, and ADRB3 and silenced the expression of these receptors to observe their effects on the adipogenic differentiation stages of porcine preadipocytes. Our investigation revealed that cold stress triggers the transformation of subcutaneous white adipose tissue to beige adipose tissue in pigs by modulating adrenergic receptor levels. Meanwhile, we found that ADRB3 promotes the transformation of white adipocytes into beige adipocytes. Notably, ADRB3 enhances the expression of beige adipose tissue marker genes, consequently influencing cellular respiration and metabolism by regulating lipolysis and mitochondrial expression. Therefore, ADRB3 may serve as a pivotal gene in animal husbandry and contribute to the improvement of cold intolerance in piglets. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13080709 2073-4409 |
| Relation: | https://www.mdpi.com/2073-4409/13/8/709; https://doaj.org/toc/2073-4409 |
| DOI: | 10.3390/cells13080709 |
| URL الوصول: | https://doaj.org/article/14ddb8403d9a488994f8df32672017e8 |
| رقم الانضمام: | edsdoj.14ddb8403d9a488994f8df32672017e8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13080709 20734409 |
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| DOI: | 10.3390/cells13080709 |