التفاصيل البيبلوغرافية
| العنوان: |
Exploring the impact of 3,3’-diindolylmethane on the urinary estrogen profile of premenopausal women |
| المؤلفون: |
Mark Newman, Jaclyn Smeaton |
| المصدر: |
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Other systems of medicine |
| مصطلحات موضوعية: |
Estrogen metabolites, Estradiol, Dietary supplement, DIM, I3C, Dried urine, Other systems of medicine, RZ201-999 |
| الوصف: |
Abstract Background 3,3’-diindolylmethane (DIM) is a phytonutrient derived from cruciferous vegetables that is an often-used supplement in the complementary and alternative medicine space. The most common goal for providers when recommending DIM to their patients is to alter estrogen metabolism, yet research into DIM’s effect on the estrogen profile is lacking in the published literature. The objective of this study was to comprehensively evaluate DIM’s effect on the urinary estrogen profile. Methods In this retrospective cohort study, we analyzed data from a clinical laboratory, including urinary estrogen and estrogen metabolite concentrations. Analyte concentrations were determined from dried urine samples using a gas chromatography-tandem mass spectrometry assay. Individuals were separated into two groups, either reporting taking DIM (N = 909) or reporting not taking DIM (N = 18,385). Comparisons between individuals in these two groups were made using the Wilcoxon rank sum test. Additionally, we were also able to explore a subset of women who had laboratory results in the database before and after initiating DIM treatment (N = 53). In this subset, differences were assessed with Wilcoxon signed rank tests. Results In the larger group that was separated into women reporting either DIM use or no use, significant differences were observed in the concentrations of almost every urinary estrogen and estrogen metabolite (with the only exception being 2-methoxyestrone) in the urinary estrogen profiles of those taking DIM compared to those not taking DIM (all P values |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2662-7671 |
| Relation: |
https://doaj.org/toc/2662-7671 |
| DOI: |
10.1186/s12906-024-04708-7 |
| URL الوصول: |
https://doaj.org/article/14108f4b457d4855a90130580e6bc42f |
| رقم الانضمام: |
edsdoj.14108f4b457d4855a90130580e6bc42f |
| قاعدة البيانات: |
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