Academic Journal
The impact of dose on the real-world effectiveness of vortioxetine in outpatients with mdd in greece
| العنوان: | The impact of dose on the real-world effectiveness of vortioxetine in outpatients with mdd in greece |
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| المؤلفون: | E. Papalexi, P. Kakkavas, D. Vassos, T. Mylonaki, D. Partsafyllidis, S. Mageiria, C. Nestoris, A. Galanopoulos, A. Ettrup |
| المصدر: | European Psychiatry, Vol 64, Pp S337-S338 (2021) |
| بيانات النشر: | Cambridge University Press, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Psychiatry |
| مصطلحات موضوعية: | Non-interventional, Vortioxetine, Depression, Dose, Psychiatry, RC435-571 |
| الوصف: | Introduction The current treatment goal in Major Depressive Disorder (MDD) is functional recovery (Zimmerman M et al, 2012). However, finding the “right dose for the right patient” may be challenging and the dose-response relationship for antidepressant efficacy remains controversial (Hieronymus F et al, 2016). Efficacy evaluated by MADRS increases with higher vortioxetine doses, based on meta-analysis data (Thase ME et al, 2016). Objectives The aim of this exploratory analysis was to assess the impact of different doses on vortioxetine effectiveness in clinical practice in Greece. Methods In this non-interventional study, open-label vortioxetine was administered at a flexible dosage (5-20 mg/d). Patients receiving 5/10 mg vortioxetine (group A), at the end of the study, were compared to patients receiving 15/20mg vortioxetine (group B). At baseline, 1 and 3 months, depressive symptoms and functioning were assessed by MADRS and SDS. Multiple regression was used for the statistical analyses. Results The study included 336 MDD patients. At the end of the study, 64.3% (n=200) of patients were receiving 15/20 mg vortioxetine. Higher vortioxetine dose at month 3 was significantly correlated with higher MADRS total score at baseline (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0924-9338 1778-3585 |
| Relation: | https://www.cambridge.org/core/product/identifier/S0924933821009056/type/journal_article; https://doaj.org/toc/0924-9338; https://doaj.org/toc/1778-3585 |
| DOI: | 10.1192/j.eurpsy.2021.905 |
| URL الوصول: | https://doaj.org/article/1324b8f5745445329235b223a87daabc |
| رقم الانضمام: | edsdoj.1324b8f5745445329235b223a87daabc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09249338 17783585 |
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| DOI: | 10.1192/j.eurpsy.2021.905 |