Academic Journal
Testicular hormones mediate robust sex differences in impulsive choice in rats
| العنوان: | Testicular hormones mediate robust sex differences in impulsive choice in rats |
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| المؤلفون: | Caesar M Hernandez, Caitlin Orsini, Alexa-Rae Wheeler, Tyler W Ten Eyck, Sara M Betzhold, Chase C Labiste, Noelle G Wright, Barry Setlow, Jennifer L Bizon |
| المصدر: | eLife, Vol 9 (2020) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | sex differences, decision making, delay discounting, intertemporal choice, sex hormones, impulsivity, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Impairments in choosing optimally between immediate and delayed rewards are associated with numerous psychiatric disorders. Such ‘intertemporal’ choice is influenced by genetic and experiential factors; however, the contributions of biological sex are understudied and data to date are largely inconclusive. Rats were used to determine how sex and gonadal hormones influence choices between small, immediate and large, delayed rewards. Females showed markedly greater preference than males for small, immediate over large, delayed rewards (greater impulsive choice). This difference was neither due to differences in food motivation or reward magnitude perception, nor was it affected by estrous cycle. Ovariectomies did not affect choice in females, whereas orchiectomies increased impulsive choice in males. These data show that male rats exhibit less impulsive choice than females and that this difference is at least partly maintained by testicular hormones. These differences in impulsive choice could be linked to gender differences across multiple neuropsychiatric conditions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/58604; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.58604 |
| URL الوصول: | https://doaj.org/article/12e85b17f4214959a67d55ee804ef012 |
| رقم الانضمام: | edsdoj.12e85b17f4214959a67d55ee804ef012 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.58604 |