Academic Journal
The binding and specificity of chemokine binding proteins, through the lens of experiment and computation
| العنوان: | The binding and specificity of chemokine binding proteins, through the lens of experiment and computation |
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| المؤلفون: | Lauren E. Stark, Wenyan Guan, Michael E. Colvin, Patricia J. LiWang |
| المصدر: | Biomedical Journal, Vol 45, Iss 3, Pp 439-453 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | viral CC Chemokine Inhibitor (vCCI), 35K, Chemokine inhibitor, Chemokine binding protein, Chemokine, Molecular dynamics, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Chemokines are small proteins that are critical for immune function, being primarily responsible for the activation and chemotaxis of leukocytes. As such, many viruses, as well as parasitic arthropods, have evolved systems to counteract chemokine function in order to maintain virulence, such as binding chemokines, mimicking chemokines, or producing analogs of transmembrane chemokine receptors that strongly bind their targets. The focus of this review is the large group of chemokine binding proteins (CBP) with an emphasis on those produced by mammalian viruses. Because many chemokines mediate inflammation, these CBP could possibly be used pharmaceutically as anti-inflammatory agents. In this review, we summarize the structural properties of a diverse set of CBP and describe in detail the chemokine binding properties of the poxvirus-encoded CBP called vCCI (viral CC Chemokine Inhibitor). Finally, we describe the current and emerging capabilities of combining computational simulation, structural analysis, and biochemical/biophysical experimentation to understand, and possibly re-engineer, protein–protein interactions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2319-4170 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2319417021000925; https://doaj.org/toc/2319-4170 |
| DOI: | 10.1016/j.bj.2021.07.004 |
| URL الوصول: | https://doaj.org/article/1274ed3f53a24d4e81550af3257ad046 |
| رقم الانضمام: | edsdoj.1274ed3f53a24d4e81550af3257ad046 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23194170 |
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| DOI: | 10.1016/j.bj.2021.07.004 |