التفاصيل البيبلوغرافية
| العنوان: |
Cytotoxic Effects of Ardisiacrispin A from Labisia pumila on A549 Human Lung Cancer Cells |
| المؤلفون: |
Yeong-Geun Lee, Tae Hyun Kim, Jeong Eun Kwon, Hyunggun Kim, Se Chan Kang |
| المصدر: |
Life, Vol 14, Iss 2, p 276 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Labisia pumila, ardisiacrispin A, A549, natural product, triterpene, Science |
| الوصف: |
Background: Lung cancer is the predominant cause of cancer-related fatalities. This prompted our exploration into the anti-lung cancer efficacy of Labisia pumila, a species meticulously selected from the preliminary screening of 600 plants. Methods: Through the strategic implementation of activity-guided fractionation, ardisiacrispin A (1) was isolated utilizing sequential column chromatography. Structural characterization was achieved employing various spectroscopic methods, including nuclear magnetic resonance (NMR), mass spectrometry (MS), and infrared spectroscopy (IR). Results: L. pumila 70% EtOH extract showed significant toxicity in A549 lung cancer cells, with an IC50 value of 57.04 ± 10.28 µg/mL, as well as decreased expression of oncogenes and induced apoptosis. Compound 1, ardisiacrispin A, induced a 50% cell death response in A549 cells at a concentration of 11.94 ± 1.14 µg/mL. Conclusions: The present study successfully investigated ardisiacrispin A extracted from L. pumila leaves, employing a comprehensive spectroscopic approach encompassing NMR, IR, and MS analyses. The anti-lung cancer efficacy of ardisiacrispin A and L. pumila extract was successfully demonstrated for the first time, to the best of our knowledge. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2075-1729 |
| Relation: |
https://www.mdpi.com/2075-1729/14/2/276; https://doaj.org/toc/2075-1729 |
| DOI: |
10.3390/life14020276 |
| URL الوصول: |
https://doaj.org/article/125a4fb90dae48ccbb3bfd6530f75787 |
| رقم الانضمام: |
edsdoj.125a4fb90dae48ccbb3bfd6530f75787 |
| قاعدة البيانات: |
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