Academic Journal
Clinical Significance of SOX10 Expression in Human Pathology
| العنوان: | Clinical Significance of SOX10 Expression in Human Pathology |
|---|---|
| المؤلفون: | Hisham F. Bahmad, Aran Thiravialingam, Karthik Sriganeshan, Jeffrey Gonzalez, Veronica Alvarez, Stephanie Ocejo, Alvaro R. Abreu, Rima Avellan, Alejandro H. Arzola, Sana Hachem, Robert Poppiti |
| المصدر: | Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 10131-10158 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | SOX10, neural crest cells, melanoma, neuroectodermal tumors, mesenchymal tumors, Biology (General), QH301-705.5 |
| الوصف: | The embryonic development of neural crest cells and subsequent tissue differentiation are intricately regulated by specific transcription factors. Among these, SOX10, a member of the SOX gene family, stands out. Located on chromosome 22q13, the SOX10 gene encodes a transcription factor crucial for the differentiation, migration, and maintenance of tissues derived from neural crest cells. It plays a pivotal role in developing various tissues, including the central and peripheral nervous systems, melanocytes, chondrocytes, and odontoblasts. Mutations in SOX10 have been associated with congenital disorders such as Waardenburg–Shah Syndrome, PCWH syndrome, and Kallman syndrome, underscoring its clinical significance. Furthermore, SOX10 is implicated in neural and neuroectodermal tumors, such as melanoma, malignant peripheral nerve sheath tumors (MPNSTs), and schwannomas, influencing processes like proliferation, migration, and differentiation. In mesenchymal tumors, SOX10 expression serves as a valuable marker for distinguishing between different tumor types. Additionally, SOX10 has been identified in various epithelial neoplasms, including breast, ovarian, salivary gland, nasopharyngeal, and bladder cancers, presenting itself as a potential diagnostic and prognostic marker. However, despite these associations, further research is imperative to elucidate its precise role in these malignancies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 45120633 1467-3045 1467-3037 |
| Relation: | https://www.mdpi.com/1467-3045/45/12/633; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045 |
| DOI: | 10.3390/cimb45120633 |
| URL الوصول: | https://doaj.org/article/124159622bf0415a9f1f77c03c947356 |
| رقم الانضمام: | edsdoj.124159622bf0415a9f1f77c03c947356 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 45120633 14673045 14673037 |
|---|---|
| DOI: | 10.3390/cimb45120633 |