التفاصيل البيبلوغرافية
| العنوان: |
Early breast cancer in women aged 35 years or younger: A large national multicenter French population-based case control-matched analysis |
| المؤلفون: |
Ondine Dufour, Gilles Houvenaeghel, Jean-Marc Classe, Monique Cohen, Christelle Faure, Chafika Mazouni, Marie-Pierre Chauvet, Eva Jouve, Emile Darai, Anne-Sophie Azuar, Pierre Gimbergues, Anthony Gonçalves, Alexandre de Nonneville |
| المصدر: |
Breast, Vol 68, Iss , Pp 163-172 (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Early breast cancer, Very young patient, Under 35 years old, Prognostic of young age, Impact of age, Young breast cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Background: There is a scarcity of data exploring early breast cancer (eBC) in very young patients. We assessed shared and intrinsic prognostic factors in a large cohort of patients aged ≤35, compared to a control group aged 36 to 50. Methods: Patients ≤50 were retrospectively identified from a multicentric cohort of 23,134 eBC patients who underwent primary surgery between 1990 and 2014. Multivariate Cox analyses for DFS and OS were built. To assess the independent impact of age, 1 to 3 case-control analysis was performed by matching ≤35 and 36–50 years patients. Results: Of 6481 patients, 556 were aged ≤35, and 5925 from 36 to 50. Age ≤35 was associated with larger tumors, higher grade, ER-negativity, macroscopic lymph node involvement (pN + macro), lymphovascular invasion (LVI), mastectomy, and chemotherapy (CT) use. In multivariate analysis, age ≤35 was associated with worse DFS [HR 1.56, 95% CI 1.32–1.84; p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1532-3080 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0960977623000279; https://doaj.org/toc/1532-3080 |
| DOI: |
10.1016/j.breast.2023.02.004 |
| URL الوصول: |
https://doaj.org/article/121ebed073b543aab7c81b276d25f578 |
| رقم الانضمام: |
edsdoj.121ebed073b543aab7c81b276d25f578 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder