التفاصيل البيبلوغرافية
| العنوان: |
Effect of the composition of combined solid lipid particles with gefitinib and a photosensitizer on their size, stability and cytotoxic activity |
| المؤلفون: |
L. L. Nikolaeva, E. V. Sanarova, A. P. Kolpaksidi, S. D. Shcheglov, A. A. Rudakova, M. A. Baryshnikova, A. V. Lantsova |
| المصدر: |
Biomedical Photonics, Vol 13, Iss 2, Pp 19-25 (2024) |
| بيانات النشر: |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association", 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medical technology |
| مصطلحات موضوعية: |
solid lipid nanoparticles, aluminum phthalocyanine, gefitinib, in vitro, photoinduced activity, Medical technology, R855-855.5 |
| الوصف: |
The creation of combined nanomedicines and their controlled release under the influence of photoinduction is an actively developing branch of scientific research. This work is devoted to the development of models of solid lipid nanoparticles for a well-known antitumor drug – gefitinib in combination with a photoindicating agent – a photosensitizer from the phthalocyanine group. Nanoparticles were obtained by several methods: hot homogenization with stearic acid, sesame oil and Tween 80 and by one-step dispersion with copolymers of lactic and glycolic acids and polyvinyl alcohol. In vitro experiments when irradiating particles with a laser in the near-infrared range (about 730 nm) proved the advantage of using combined nanoparticles with gefitinib and a photosensitizer compared to monotherapy, while the activity in terms of IC50 was 5.1-8.7 times higher for gefitinib and 1.5-1.8 times for the photosensitizer. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
Russian |
| تدمد: |
2413-9432 |
| Relation: |
https://www.pdt-journal.com/jour/article/view/649; https://doaj.org/toc/2413-9432 |
| DOI: |
10.24931/2413-9432-2023-13-1-19-25 |
| URL الوصول: |
https://doaj.org/article/11c3541c112146c989a7da986d6010b1 |
| رقم الانضمام: |
edsdoj.11c3541c112146c989a7da986d6010b1 |
| قاعدة البيانات: |
Directory of Open Access Journals |