التفاصيل البيبلوغرافية
| العنوان: |
Transcatheter aortic valve replacement in patients with aortic stenosis and cardiac amyloidosis |
| المؤلفون: |
Tasveer Khawaja, Rahul Jaswaney, Shilpkumar Arora, Akhil Jain, Nirav Arora, Luis Augusto Palma Dallan, Sunghan Yoon, Mohammed Najeeb Osman, Steven J. Filby, Guilherme F. Attizzani |
| المصدر: |
International Journal of Cardiology: Heart & Vasculature, Vol 40, Iss , Pp 101008- (2022) |
| بيانات النشر: |
Elsevier, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
Aortic stenosis, Cardiac amyloidosis, TAVR, Heart failure, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
Background: Though the co-prevalence of aortic stenosis (AS) and cardiac amyloidosis (CA) is increasingly recognized, the role of transcatheter aortic valve replacement (TAVR) in patients with CA remains unclear. Methods: The National Readmission Dataset (2016–18) and ICD-10 codes were used to identify those with CA and AS, in conjunction with TAVR status. The primary outcome was a composite of heart failure (HF) readmissions and all-cause mortality. All outcomes were followed up to 1-year with a median follow up time 172-days. Kaplan-Meier curves and multivariate cox-proportional hazard regression were used for time-to-event analysis. Results: Of 1,127 CA patients, 92 (8.2%) had undergone TAVR. Patients with CA who received TAVR were younger and more commonly had coronary artery disease (67.3% vs 44.2%). Teaching (93.6% vs 81.1%) and large hospitals (77.7% vs 59.3%) performed more TAVRs. In multivariate analysis, TAVR was associated with an improved primary outcome (8.9% vs 24.4%, HR:0.32; 95% CI 0.14–0.71, p = 0.007) and with reduced HF readmissions (3.8% vs 19.4%, HR:0.22; 95% CI 0.07–0.68, p = 0.008). All-cause mortality was numerically lower in TAVR patients with CA but did not reach statistical significance. Conclusions: CA patients who receive TAVR are younger, and the procedure is more commonly performed at large, teaching hospitals. TAVR was associated with a lower primary composite outcome of HF readmissions and all-cause mortality. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2352-9067 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2352906722000574; https://doaj.org/toc/2352-9067 |
| DOI: |
10.1016/j.ijcha.2022.101008 |
| URL الوصول: |
https://doaj.org/article/c10a2ee211d24caabe24d81ea9186d8d |
| رقم الانضمام: |
edsdoj.10a2ee211d24caabe24d81ea9186d8d |
| قاعدة البيانات: |
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