Academic Journal
High Prevalence of Human Cytomegalovirus in Brain Metastases of Patients with Primary Breast and Colorectal Cancers
| العنوان: | High Prevalence of Human Cytomegalovirus in Brain Metastases of Patients with Primary Breast and Colorectal Cancers |
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| المؤلفون: | Chato Taher, Gabriella Frisk, Stina Fuentes, Piotr Religa, Helena Costa, Alice Assinger, Katja Kannisto Vetvik, Ida R.K. Bukholm, Koon-Chu Yaiw, Karin Ekström Smedby, Magnus Bäcklund, Cecilia Söderberg-Naucler, Afsar Rahbar |
| المصدر: | Translational Oncology, Vol 7, Iss 6, Pp 732-740 (2014) |
| بيانات النشر: | Elsevier, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | BACKGROUND: Brain metastases (BMs) develop by largely unknown mechanisms and cause major morbidity and mortality in patients with solid tumors. Human cytomegalovirus (HCMV) is frequently detected in tumor tissue from patients with different cancers. Here, we aimed to determine the prevalence and potential prognostic role of HCMV in BMs. METHODS: We obtained archived samples of BMs from 41 patients with breast cancer and 37 with colorectal cancer and paired primary tumor tissues from 13 and 12 patients in each respective group. In addition, primary breast cancer tissues from 15 patients were included. HCMV proteins were detected with an immunohistochemical technique and Western blot. HCMV nucleic acids were detected with TaqMan polymerase chain reaction (PCR) assay. RESULTS: HCMV proteins were abundantly expressed in 99% of BM specimens, and in 12 of 13 (92%) paired primary breast cancer specimens. All 12 paired colon cancer samples were positive for HCMV proteins. Protein staining was mainly confined to neoplastic cells. Western blot analysis detected an HCMV-IE reactive protein in 53% of breast cancer specimens, and PCR detected the presence of HCMV DNA and transcripts in 92% and 80% of samples, respectively. Patients with high-level expression of HCMV-IE proteins in their tumors had a shorter time to tumor progression and shorter overall survival. CONCLUSIONS: The prevalence of HCMV proteins and nucleic acids is very high in primary and metastatic tumors and may drive the development of metastatic brain tumors; therefore, this virus may represent a potential therapeutic target in metastatic cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1936-5233 1944-7124 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1936523314001016; https://doaj.org/toc/1936-5233; https://doaj.org/toc/1944-7124 |
| DOI: | 10.1016/j.tranon.2014.09.008 |
| URL الوصول: | https://doaj.org/article/e0ff9fa5365c409cb215a9a223fd27d8 |
| رقم الانضمام: | edsdoj.0ff9fa5365c409cb215a9a223fd27d8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19365233 19447124 |
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| DOI: | 10.1016/j.tranon.2014.09.008 |