التفاصيل البيبلوغرافية
| العنوان: |
Refugia and anthelmintic resistance: Concepts and challenges |
| المؤلفون: |
Jane E. Hodgkinson, Ray M. Kaplan, Fiona Kenyon, Eric R. Morgan, Andrew W. Park, Steve Paterson, Simon A. Babayan, Nicola J. Beesley, Collette Britton, Umer Chaudhry, Stephen R. Doyle, Vanessa O. Ezenwa, Andy Fenton, Sue B. Howell, Roz Laing, Barbara K. Mable, Louise Matthews, Jennifer McIntyre, Catherine E. Milne, Thomas A. Morrison, Jamie C. Prentice, Neil D. Sargison, Diana J.L. Williams, Adrian J. Wolstenholme, Eileen Devaney |
| المصدر: |
International Journal for Parasitology: Drugs and Drug Resistance, Vol 10, Iss , Pp 51-57 (2019) |
| بيانات النشر: |
Elsevier, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: |
Infectious and parasitic diseases, RC109-216 |
| الوصف: |
Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in ‘refugia’, unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that factors potentially important to refugia, such as the fitness cost of drug resistance, the degree of mixing between parasite sub-populations selected through treatment or not, and the impact of parasite life-history, genetics and environment on the population dynamics of resistance, vary widely between systems. The success of attempts to generate refugia to limit anthelmintic drug resistance are therefore likely to be highly dependent on the system in hand. Additional research is needed on the concept of refugia and the underlying principles for its application across systems, as well as empirical studies within systems that prove and optimise its usefulness. Keywords: Refugia, Anthelmintic drug, Resistance, Parasite, Control, Fitness |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2211-3207 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211320719300508; https://doaj.org/toc/2211-3207 |
| DOI: |
10.1016/j.ijpddr.2019.05.001 |
| URL الوصول: |
https://doaj.org/article/0f597d86787e47a29603f6805ad59e1f |
| رقم الانضمام: |
edsdoj.0f597d86787e47a29603f6805ad59e1f |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder