التفاصيل البيبلوغرافية
| العنوان: |
Application of Feedback System Control Optimization Technique in Combined Use of Dual Antiplatelet Therapy and Herbal Medicines |
| المؤلفون: |
Wang Liu, Yu-Long Li, Mu-Ting Feng, Yu-Wei Zhao, Xianting Ding, Ben He, Xuan Liu |
| المصدر: |
Frontiers in Physiology, Vol 9 (2018) |
| بيانات النشر: |
Frontiers Media S.A., 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Physiology |
| مصطلحات موضوعية: |
feedback system control, dual antiplatelet therapy, herbal medicine, platelet aggregation, optimization, synergism, Physiology, QP1-981 |
| الوصف: |
Aim: Combined use of herbal medicines in patients underwent dual antiplatelet therapy (DAPT) might cause bleeding or thrombosis because herbal medicines with anti-platelet activities may exhibit interactions with DAPT. In this study, we tried to use a feedback system control (FSC) optimization technique to optimize dose strategy and clarify possible interactions in combined use of DAPT and herbal medicines.Methods: Herbal medicines with reported anti-platelet activities were selected by searching related references in Pubmed. Experimental anti-platelet activities of representative compounds originated from these herbal medicines were investigated using in vitro assay, namely ADP-induced aggregation of rat platelet-rich-plasma. FSC scheme hybridized artificial intelligence calculation and bench experiments to iteratively optimize 4-drug combination and 2-drug combination from these drug candidates.Results: Totally 68 herbal medicines were reported to have anti-platelet activities. In the present study, 7 representative compounds from these herbal medicines were selected to study combinatorial drug optimization together with DAPT, i.e., aspirin and ticagrelor. FSC technique first down-selected 9 drug candidates to the most significant 5 drugs. Then, FSC further secured 4 drugs in the optimal combination, including aspirin, ticagrelor, ferulic acid from DangGui, and forskolin from MaoHouQiaoRuiHua. Finally, FSC quantitatively estimated the possible interactions between aspirin:ticagrelor, aspirin:ferulic acid, ticagrelor:forskolin, and ferulic acid:forskolin. The estimation was further verified by experimentally determined Combination Index (CI) values.Conclusion: Results of the present study suggested that FSC optimization technique could be used in optimization of anti-platelet drug combinations and might be helpful in designing personal anti-platelet therapy strategy. Furthermore, FSC analysis could also identify interactions between different drugs which might provide useful information for research of signal cascades in platelet. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-042X |
| Relation: |
http://journal.frontiersin.org/article/10.3389/fphys.2018.00491/full; https://doaj.org/toc/1664-042X |
| DOI: |
10.3389/fphys.2018.00491 |
| URL الوصول: |
https://doaj.org/article/0edc129ac7c644b9af703602c1587bd7 |
| رقم الانضمام: |
edsdoj.0edc129ac7c644b9af703602c1587bd7 |
| قاعدة البيانات: |
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