Academic Journal
T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance
| العنوان: | T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance |
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| المؤلفون: | Xin Gao, Kaiming Luo, Diya Wang, Yunbo Wei, Yin Yao, Jun Deng, Yang Yang, Qunxiong Zeng, Xiaoru Dong, Le Xiong, Dongcheng Gong, Lin Lin, Kai Pohl, Shaoling Liu, Yu Liu, Lu Liu, Thi HO Nguyen, Lilith F Allen, Katherine Kedzierska, Yanliang Jin, Mei-Rong Du, Wanping Chen, Liangjing Lu, Nan Shen, Zheng Liu, Ian A Cockburn, Wenjing Luo, Di Yu |
| المصدر: | eLife, Vol 12 (2023) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | Tfh, vaccine, antibody, memory, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | A defining feature of successful vaccination is the ability to induce long-lived antigen-specific memory cells. T follicular helper (Tfh) cells specialize in providing help to B cells in mounting protective humoral immunity in infection and after vaccination. Memory Tfh cells that retain the CXCR5 expression can confer protection through enhancing humoral response upon antigen re-exposure but how they are maintained is poorly understood. CXCR5+ memory Tfh cells in human blood are divided into Tfh1, Tfh2, and Tfh17 cells by the expression of chemokine receptors CXCR3 and CCR6 associated with Th1 and Th17, respectively. Here, we developed a new method to induce Tfh1, Tfh2, and Tfh17-like (iTfh1, iTfh2, and iTfh17) mouse cells in vitro. Although all three iTfh subsets efficiently support antibody responses in recipient mice with immediate immunization, iTfh17 cells are superior to iTfh1 and iTfh2 cells in supporting antibody response to a later immunization after extended resting in vivo to mimic memory maintenance. Notably, the counterpart human Tfh17 cells are selectively enriched in CCR7+ central memory Tfh cells with survival and proliferative advantages. Furthermore, the analysis of multiple human cohorts that received different vaccines for HBV, influenza virus, tetanus toxin or measles revealed that vaccine-specific Tfh17 cells outcompete Tfh1 or Tfh2 cells for the persistence in memory phase. Therefore, the complementary mouse and human results showing the advantage of Tfh17 cells in maintenance and memory function supports the notion that Tfh17-induced immunization might be preferable in vaccine development to confer long-term protection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/82217; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.82217 |
| URL الوصول: | https://doaj.org/article/0eabb4a380504fd2b49c62eeba348d05 |
| رقم الانضمام: | edsdoj.0eabb4a380504fd2b49c62eeba348d05 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.82217 |