التفاصيل البيبلوغرافية
| العنوان: |
The MeshCODE to scale—visualising synaptic binary information |
| المؤلفون: |
Samuel F. H. Barnett, Benjamin T. Goult |
| المصدر: |
Frontiers in Cellular Neuroscience, Vol 16 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
integrin, talin, vinculin, cytoskeleton, actin, dendritic spine, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
The Mercator projection map of the world provides a useful, but distorted, view of the relative scale of countries. Current cellular models suffer from a similar distortion. Here, we undertook an in-depth structural analysis of the molecular dimensions in the cell’s computational machinery, the MeshCODE, that is assembled from a meshwork of binary switches in the scaffolding proteins talin and vinculin. Talin contains a series of force-dependent binary switches and each domain switching state introduces quantised step-changes in talin length on a micrometre scale. The average dendritic spine is 1 μm in diameter so this analysis identifies a plausible Gearbox-like mechanism for dynamic regulation of synaptic function, whereby the positioning of enzymes and substrates relative to each other, mechanically-encoded by the MeshCODE switch patterns, might control synaptic transmission. Based on biophysical rules and experimentally derived distances, this analysis yields a novel perspective on biological digital information. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1662-5102 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fncel.2022.1014629/full; https://doaj.org/toc/1662-5102 |
| DOI: |
10.3389/fncel.2022.1014629 |
| URL الوصول: |
https://doaj.org/article/0e9ea65beb5d4322b3de1974ba450822 |
| رقم الانضمام: |
edsdoj.0e9ea65beb5d4322b3de1974ba450822 |
| قاعدة البيانات: |
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