Academic Journal
Lymphocyte homeostasis is maintained in perinatally HIV-infected patients after three decades of life
| العنوان: | Lymphocyte homeostasis is maintained in perinatally HIV-infected patients after three decades of life |
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| المؤلفون: | S. Paghera, E. Quiros-Roldan, A. Sottini, M. Properzi, F. Castelli, L. Imberti |
| المصدر: | Immunity & Ageing, Vol 16, Iss 1, Pp 1-10 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Geriatrics |
| مصطلحات موضوعية: | Perinatal HIV infection, Immunosenescence, T-cell receptor repertoire, Telomere length, Thymic and bone marrow output, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Background While immunosenescence, defined as reduced production of new lymphocytes, restriction of T-cell receptor repertoire and telomeres shortening, has been extensively evaluated in HIV-infected children and adults, no data about these parameters are available in perinatally-infected patients with very long-lasting HIV infection. Methods We compared thymic and bone marrow output, telomere length (measured by Real-Time PCR) and T-cell receptor repertoire (determined by spectratyping) of 21 perinatally HIV-infected subjects (with a median of 27 years of infection) with those of 19 age-matched non-perinatally HIV-infected patients and 40 healthy controls. All patients received a combined antiretroviral therapy. Results While thymic and bone marrow output were not different among the analyzed groups, telomere length in peripheral blood cells and T-cell receptor diversity were significantly lower in HIV-perinatally and non-perinatally infected individuals compared to healthy controls. Conclusions In HIV-infected subjects, a normal thymic output together with a reduced telomere length and a restricted T-cell receptor repertoire could be explained by the shift of newly produced cells into memory subsets. This phenomenon may allow to control viral infection and maintain peripheral homeostasis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1742-4933 |
| Relation: | http://link.springer.com/article/10.1186/s12979-019-0166-7; https://doaj.org/toc/1742-4933 |
| DOI: | 10.1186/s12979-019-0166-7 |
| URL الوصول: | https://doaj.org/article/0e1ef562a8ee4e0dacfde44edf1cf28f |
| رقم الانضمام: | edsdoj.0e1ef562a8ee4e0dacfde44edf1cf28f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17424933 |
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| DOI: | 10.1186/s12979-019-0166-7 |