التفاصيل البيبلوغرافية
| العنوان: |
The use of serum bepridil concentration as a safe rhythm control strategy in patients with atrial tachyarrhythmias |
| المؤلفون: |
Seiji Miura, MD, Masataka Sumiyoshi, MD, Hiroto Tsuchiya, MD, Masaki Maruyama, MD, I Seigen, MD, Iwao Okai, MD, Yoshiyuki Masaki, MD, Shinya Okazaki, MD, Kenji Inoue, MD, Yasumasa Fujiwara, MD, Kaoru Komatsu, MD, Hidemori Hayashi, MD, Gaku Sekita, MD, Takashi Tokano, MD, Yuji Nakazato, MD, Hiroyuki Daida, MD |
| المصدر: |
Journal of Arrhythmia, Vol 28, Iss 3, Pp 187-191 (2012) |
| بيانات النشر: |
Wiley, 2012. |
| سنة النشر: |
2012 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
Serum concentration, Atrial tachyarrhythmia, QT interval, QTc, Proarrhythmia, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
The aim of this study was to evaluate the clinical significance of serum bepridil (Bep) concentration (SBC) for safely managing patients with atrial tachyarrhythmias (AT). Methods and results: SBC was measured in 37 patients with AT, including atrial fribrillation (AF) (31 cases), AF+atrial flutter (AFL) (4 cases), AFL (1 case), and atrial tachycardia (1 case). The patients were administrated Bep for more than 4 weeks at the same dose. SBC was positively correlated with Bep dose per kilogram of body weight (p=0.015), QT interval (p=0.019), and QTc (p=0.034). The patients were divided into 2 groups according to their SBC: the high-SBC (HSBC) group of 8 patients with an SBC≥500 ng/ml and a low-SBC (LSBC) group of 29 patients with an SBC0.5 were more prominent in the HSBC group (37.5% vs. 3.4%, p=0.026), and torsade de points (TdP) occurred in only one patient in the HSBC group. However, there were several patients with normal QT/QTc despite having high SBC. Conclusions: In patients treated with Bep, measurement of SBC is useful for preventing proarrhythmias. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1880-4276 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S188042761200052X; https://doaj.org/toc/1880-4276 |
| DOI: |
10.1016/j.joa.2012.02.015 |
| URL الوصول: |
https://doaj.org/article/0e03aed79e87427c9c0532e8d79c6338 |
| رقم الانضمام: |
edsdoj.0e03aed79e87427c9c0532e8d79c6338 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder