التفاصيل البيبلوغرافية
| العنوان: |
Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin |
| المؤلفون: |
Kirill Grushin, Jing Wang, Jeff Coleman, James E. Rothman, Charles V. Sindelar, Shyam S. Krishnakumar |
| المصدر: |
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| بيانات النشر: |
Nature Portfolio, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
The neuronal Ca2+-sensor Synapotagmin-1 (Syt1) interacts with SNARE proteins and lipid membranes and synchronizes neurotransmitter release in response to Ca2+-influx. Here the authors provide insights into the underlying molecular mechanism by determining the cryo-EM structure of the Syt1–SNARE complex on a lipid membrane at 10 Å resolution. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-10391-x |
| URL الوصول: |
https://doaj.org/article/0d3353b42fb54d0b8fe35dd6b8452acc |
| رقم الانضمام: |
edsdoj.0d3353b42fb54d0b8fe35dd6b8452acc |
| قاعدة البيانات: |
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