Academic Journal
Respiratory syncytial virus hospitalizations in infants of 28 weeks gestational age and less in the palivizumab era
| العنوان: | Respiratory syncytial virus hospitalizations in infants of 28 weeks gestational age and less in the palivizumab era |
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| المؤلفون: | Bernhard Resch, Beatrice Egger, Stefan Kurath-Koller, Berndt Urlesberger |
| المصدر: | International Journal of Infectious Diseases, Vol 57, Iss C, Pp 50-53 (2017) |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | bronchopulmonary dysplasia, palivizumab, preterm infant, respiratory syncytial virus, respiratory tract infection, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Objective: To obtain data on respiratory syncytial virus (RSV) associated hospitalization rates in preterm infants of 28 weeks gestational age and less in the era of palivizumab prophylaxis. Methods: Retrospective single-center cohort study including all preterm infants up to 28 weeks + 6 days gestational age and born between 2004 and 2012 at a tertiary care university hospital. Data on RSV related hospitalizations over the first two years of life covering at least two RSV seasons (November-April) were analyzed. Results: Ninety-one of 287 (32%) infants were hospitalized due to respiratory illness, and a total of 17 infants (5.9%) tested RSV positive during the first 2 years of life. Fourteen infants (4.9%) were hospitalized during the first RSV season. RSV hospitalization rate in infants with BPD was 4.5% (2/44) compared to 4.9% (12/243) without BPD. Palivizumab prophylaxis was documented in 74.6% of the infants. Infants with RSV compared to other respiratory tract infection were of younger age (6.8 vs. 9.1 months; p = 0.049), had longer hospital stays (median 11 vs. 5 days; p = 0.043) and more severe respiratory illness (median LRI score 3 vs. 2; p = 0.043). Conclusions: Despite palivizumab prophylaxis the burden of RSV disease and all cause respiratory illness was still remarkable in this vulnerable preterm population and mainly limited to the first season. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1201-9712 1878-3511 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1201971217300371; https://doaj.org/toc/1201-9712; https://doaj.org/toc/1878-3511 |
| DOI: | 10.1016/j.ijid.2017.01.034 |
| URL الوصول: | https://doaj.org/article/0d2e469c03394ee5828c6297c3f39370 |
| رقم الانضمام: | edsdoj.0d2e469c03394ee5828c6297c3f39370 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 12019712 18783511 |
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| DOI: | 10.1016/j.ijid.2017.01.034 |