التفاصيل البيبلوغرافية
| العنوان: |
Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets |
| المؤلفون: |
Mandy Sonntag, Maren Blosa, Sophie Schmidt, Katja Reimann, Kerstin Blum, Tobias Eckrich, Gudrun Seeger, Dietmar Hecker, Bernhard Schick, Thomas Arendt, Jutta Engel, Markus Morawski |
| المصدر: |
BMC Biology, Vol 16, Iss 1, Pp 1-18 (2018) |
| بيانات النشر: |
BMC, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
Brevican, Cochlea, Inner hair cell, Ribbon synapse, Extracellular matrix, Perineuronal net, Biology (General), QH301-705.5 |
| الوصف: |
Abstract Background Perineuronal nets (PNNs) are specialized aggregations of extracellular matrix (ECM) molecules surrounding specific neurons in the central nervous system (CNS). PNNs are supposed to control synaptic transmission and are frequently associated with neurons firing at high rates, including principal neurons of auditory brainstem nuclei. The origin of high-frequency activity of auditory brainstem neurons is the indefatigable sound-driven transmitter release of inner hair cells (IHCs) in the cochlea. Results Here, we show that synaptic poles of IHCs are ensheathed by basket-like ECM complexes formed by the same molecules that constitute PNNs of neurons in the CNS, including brevican, aggreccan, neurocan, hyaluronan, and proteoglycan link proteins 1 and 4 and tenascin-R. Genetic deletion of brevican, one of the main components, resulted in a massive degradation of ECM baskets at IHCs, a significant impairment in spatial coupling of pre- and postsynaptic elements and mild impairment of hearing. Conclusions These ECM baskets potentially contribute to control of synaptic transmission at IHCs and might be functionally related to PNNs of neurons in the CNS. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1741-7007 |
| Relation: |
http://link.springer.com/article/10.1186/s12915-018-0566-8; https://doaj.org/toc/1741-7007 |
| DOI: |
10.1186/s12915-018-0566-8 |
| URL الوصول: |
https://doaj.org/article/0cbf0673ed574acb9e63b8c16b5b13fa |
| رقم الانضمام: |
edsdoj.0cbf0673ed574acb9e63b8c16b5b13fa |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder