Academic Journal
Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing
| العنوان: | Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing |
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| المؤلفون: | Anna J. Stevenson, Daniel L. McCartney, Sarah E. Harris, Adele M. Taylor, Paul Redmond, John M. Starr, Qian Zhang, Allan F. McRae, Naomi R. Wray, Tara L. Spires-Jones, Barry W. McColl, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni |
| المصدر: | Clinical Epigenetics, Vol 10, Iss 1, Pp 1-10 (2018) |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | Inflammation, DNA methylation, Epigenetics, Epigenetic age acceleration, Immune cells, Medicine, Genetics, QH426-470 |
| الوصف: | Abstract Background Epigenetic age acceleration (an older methylation age compared to chronological age) correlates strongly with various age-related morbidities and mortality. Chronic systemic inflammation is thought to be a hallmark of ageing, but the relationship between an increased epigenetic age and this likely key phenotype of ageing has not yet been extensively investigated. Methods We modelled the trajectories of the inflammatory biomarkers C-reactive protein (CRP; measured using both a high- and low-sensitivity assay) and interleukin-6 (IL-6) over the eighth decade in the Lothian Birth Cohort 1936. Using linear mixed models, we investigated the association between CRP and immune cell profiles imputed from the methylation data and examined the cross-sectional and longitudinal association between the inflammatory biomarkers and two measures of epigenetic age acceleration, derived from the Horvath and Hannum epigenetic clocks. Results We found that low-sensitivity CRP declined, high-sensitivity CRP did not change, and IL-6 increased over time within the cohort. CRP levels inversely associated with CD8+T cells and CD4+T cells and positively associated with senescent CD8+T cells, plasmablasts and granulocytes. Cross-sectionally, the Hannum, but not the Horvath, measure of age acceleration was positively associated with each of the inflammatory biomarkers, including a restricted measure of CRP (≤ 10 mg/L) likely reflecting levels relevant to chronic inflammation. Conclusions We found a divergent relationship between inflammation and immune system parameters in older age. We additionally report the Hannum measure of epigenetic age acceleration associated with an elevated inflammatory profile cross-sectionally, but not longitudinally. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1868-7075 1868-7083 |
| Relation: | http://link.springer.com/article/10.1186/s13148-018-0585-x; https://doaj.org/toc/1868-7075; https://doaj.org/toc/1868-7083 |
| DOI: | 10.1186/s13148-018-0585-x |
| URL الوصول: | https://doaj.org/article/0c706a1df6694049b0d814a5455edd67 |
| رقم الانضمام: | edsdoj.0c706a1df6694049b0d814a5455edd67 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18687075 18687083 |
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| DOI: | 10.1186/s13148-018-0585-x |