التفاصيل البيبلوغرافية
| العنوان: |
Clinicopathological Characteristics and Prognosis of Borrmann Type Ⅳ Gastric Cancer |
| المؤلفون: |
DING Pingan, YANG Peigang, TIAN Yuan, LIN Yecheng, GUO Honghai, LIU Yang, ZHANG Zhidong, WANG Dong, LI Yong, ZHAO Qun |
| المصدر: |
Zhongliu Fangzhi Yanjiu, Vol 48, Iss 3, Pp 261-267 (2021) |
| بيانات النشر: |
Magazine House of Cancer Research on Prevention and Treatment, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
gastric neoplasms, borrmann type ⅳ, clinicopathological characteristics, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Objective To investigate the clinicopathological characteristics and prognosis of patients with Borrmann type Ⅳ gastric cancer. Methods A cohort retrospective analysis of 2386 patients with gastric cancer who underwent radical surgery was used to screen out Borrmann type Ⅳ patients, and analyze their clinical features and prognostic factors. Results Among 2386 patients with gastric cancer, 363 cases (15.21%) were Borrmann type Ⅳ. Compared with non-Borrmann type Ⅳ gastric cancer patients, Borrmann type Ⅳ patients had higher rates of simultaneous liver metastasis, metachronous liver metastasis, lymph node metastasis and vascular infiltration. Moreover, the age of onset tended to be younger and the pathological type tended to be poorly differentiated-undifferentiated (all P < 0.05). The 5-year OS of the entire group was 49.32% and the 5-year DFS was 44.61%. There were significant differences in 5-year OS and DFS between Borrmann type Ⅳ and non-Borrmann type Ⅳpatients (all P < 0.001). The subgroup analyses showed that there were statistically significant differences in 5-year OS and DFS of gastric cancer patients between Borrmann type Ⅳ and non-Borrmann type Ⅳ in pT2-pT4a and pN0-pN3a stages (all P < 0.005). Multivariate analysis showed that the poorly differentiated-undifferentiated tumor, the T4a-pT4b stage of tumor invasion depth, lymph node metastasis, the ⅢA-ⅢC pTNM stage of the tumor, postoperative liver metastasis and peritoneal metastasis were independent risk factors affecting the prognosis of Borrmann type Ⅳ gastric cancer patients (all P < 0.05). Conclusion Borrmann type Ⅳ gastric cancer is prone to liver metastasis, lymph node metastasis, peritoneal metastasis and poor prognosis, and it's prognosis is affected by a variety of independent risk factors. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
Chinese |
| تدمد: |
1000-8578 |
| Relation: |
http://html.rhhz.net/ZLFZYJ/html/8578.2021.20.0770.htm; https://doaj.org/toc/1000-8578 |
| DOI: |
10.3971/j.issn.1000-8578.2021.20.0770 |
| URL الوصول: |
https://doaj.org/article/0c65817bd6044464b5fff17ad6eca0cd |
| رقم الانضمام: |
edsdoj.0c65817bd6044464b5fff17ad6eca0cd |
| قاعدة البيانات: |
Directory of Open Access Journals |